madman
Super Moderator
Abstract
Purpose of Review
To review novel, non-surgical therapies for erectile dysfunction (ED).
Recent Findings
Recently, a landmark study identified the SIM1 locus, involved in the leptin-melanocortin pathway, as an independent risk factor for ED and a potential target for novel therapies. The recent literature otherwise has focused on low intensity shock wave therapy (LiSWT), with several randomized trials and meta-analyses suggesting therapeutic efficacy.
Summary
There are few novel oral agents for ED. There is growing evidence suggesting efficacy of intracavernosal stem cells therapy and low-intensity shock wave therapy (LiSWT), although these therapies are still investigational. A better understanding of the pathophysiologic spectrum of ED will offer new opportunities for novel, non-surgical therapies for ED. Keywords Erectile
Conclusions
We have developed a better understanding of the pathophysiology of ED over the last decade. However, this has not translated to novel non-surgical therapies, especially novel oral therapies. Other innovative therapies including stem cell therapy and LiSWT are in early clinical stages show promise, but there remain unanswered questions about patient selection and efficacy. A better understanding of the pathophysiologic spectrum of ED and further technological advances will translate to novel therapies for ED in the future.
Purpose of Review
To review novel, non-surgical therapies for erectile dysfunction (ED).
Recent Findings
Recently, a landmark study identified the SIM1 locus, involved in the leptin-melanocortin pathway, as an independent risk factor for ED and a potential target for novel therapies. The recent literature otherwise has focused on low intensity shock wave therapy (LiSWT), with several randomized trials and meta-analyses suggesting therapeutic efficacy.
Summary
There are few novel oral agents for ED. There is growing evidence suggesting efficacy of intracavernosal stem cells therapy and low-intensity shock wave therapy (LiSWT), although these therapies are still investigational. A better understanding of the pathophysiologic spectrum of ED will offer new opportunities for novel, non-surgical therapies for ED. Keywords Erectile
Conclusions
We have developed a better understanding of the pathophysiology of ED over the last decade. However, this has not translated to novel non-surgical therapies, especially novel oral therapies. Other innovative therapies including stem cell therapy and LiSWT are in early clinical stages show promise, but there remain unanswered questions about patient selection and efficacy. A better understanding of the pathophysiologic spectrum of ED and further technological advances will translate to novel therapies for ED in the future.
