madman
Super Moderator
Abstract
Ibuprofen is a widely used analgesic/antipyretic medication belongs to the nonsteroidal anti‐inflammatory class. Even though the influence of ibuprofen on semen quality has been investigated in various occasions, the comprehensive understanding and discussion of its impact on semen quality is still yet to be determined. In this work, we systematically review and reveal the effect of ibuprofen on semen quality, and thus on fertilising capability. To achieve this goal, we searched the main research databases (Scopus and PubMed) from 1 June 1986 through 13 October 2018 for English language articles and abstracts using the keywords “ibuprofen” versus “semen” and “sperm”. In addition, related published articles or abstracts were also discussed if relevant. Altogether, the main stream of research, from both in vitro and in vivo studies, presents an adverse effect of ibuprofen on different sperm parameters such as motility, viability, count and DNA integrity; however, such effect is not yet confirmed in humans. Mechanisms by which ibuprofen affects semen quality may be by reducing testosterone and prostaglandin synthesis, chelating zinc ions and inhibiting nitric oxide synthesis. However, further research studies, mainly clinical, are still of great importance to confirm the effects of ibuprofen on semen quality.
3.6 | Conclusions and future perspectives
In conclusion, the main stream of research studies (mainly in vivo system studies) demonstrates the presence of adverse effects of the use of ibuprofen, at different doses, on almost all sperm parameters such as motility, viability, count, morphology and DNA integrity. However, such effects are not yet established in humans due to the lack of research studies and research consensus. The adverse effects of ibuprofen on sperm parameters may be due to reduction in testosterone and prostaglandin synthesis, zinc‐chelating activity of ibuprofen and inhibition of nitric oxide production.
While, collectively, further research studies, mainly clinical, are still of great importance to disclose the effects of ibuprofen on semen quality and sperm physiology, and hence on the ability of fertilisation. Our laboratory is now designing a long‐term human research study to explore the effect of ibuprofen on sperm parameters, mainly sperm DNA damage
Ibuprofen is a widely used analgesic/antipyretic medication belongs to the nonsteroidal anti‐inflammatory class. Even though the influence of ibuprofen on semen quality has been investigated in various occasions, the comprehensive understanding and discussion of its impact on semen quality is still yet to be determined. In this work, we systematically review and reveal the effect of ibuprofen on semen quality, and thus on fertilising capability. To achieve this goal, we searched the main research databases (Scopus and PubMed) from 1 June 1986 through 13 October 2018 for English language articles and abstracts using the keywords “ibuprofen” versus “semen” and “sperm”. In addition, related published articles or abstracts were also discussed if relevant. Altogether, the main stream of research, from both in vitro and in vivo studies, presents an adverse effect of ibuprofen on different sperm parameters such as motility, viability, count and DNA integrity; however, such effect is not yet confirmed in humans. Mechanisms by which ibuprofen affects semen quality may be by reducing testosterone and prostaglandin synthesis, chelating zinc ions and inhibiting nitric oxide synthesis. However, further research studies, mainly clinical, are still of great importance to confirm the effects of ibuprofen on semen quality.
3.6 | Conclusions and future perspectives
In conclusion, the main stream of research studies (mainly in vivo system studies) demonstrates the presence of adverse effects of the use of ibuprofen, at different doses, on almost all sperm parameters such as motility, viability, count, morphology and DNA integrity. However, such effects are not yet established in humans due to the lack of research studies and research consensus. The adverse effects of ibuprofen on sperm parameters may be due to reduction in testosterone and prostaglandin synthesis, zinc‐chelating activity of ibuprofen and inhibition of nitric oxide production.
While, collectively, further research studies, mainly clinical, are still of great importance to disclose the effects of ibuprofen on semen quality and sperm physiology, and hence on the ability of fertilisation. Our laboratory is now designing a long‐term human research study to explore the effect of ibuprofen on sperm parameters, mainly sperm DNA damage
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