E2 and cancer

[JimBob]

My nurse told me she gets concerned if a man's E2 hits 70 due to increased risk of cancer. I did some Googling and came up empty except for a possible increase in breast cancer risk(for men). Is there any strong correlation between elevated E2 and cancer in men?

Men With High Estrogen Levels Could Have Increased Breast Cancer Risk

An international study has found that men with naturally high levels of estrogen may have a higher-than-average risk of breast cancer.

www.breastcancer.org

 

[Vince]

If you're getting the right estradiol sensitive (LC/MS-MS) test. 60 should be the above limit in my opinion. There's more issues with low E2, that high levels.

I've never heard of anyone getting cancer from high levels of E2. Think how much higher women levels are.

 

[JimBob]

Why should 60 be the upper limit?

 

[Vince]

Why should 60 be the upper limit?

I watched a interviewed, that Nelson had with a doctor. He mentioned 60 being the upper limit. I've never had to test that limit, so personally I wouldn't know.

 

[JimBob]

I just wonder what this limit is based upon. Hopefully it's not based on the average E2 levels of an older, obese/sick population, like testosterone levels have been. Seems purely arbitrary. Thanks, Vince, for replying.

 

[JimGainz]

For what it’s worth, when I eliminated my AI, my estrogen level rose into the 80s and 90s. There are a lot of threads and experts saying that this is perfectly fine but it just didn’t resonate with me. I take a low-dose AI and try to keep mine under 50. I feel better and look better. I am not in the camp of just letting estrogen run wild.

 

[Match]

From what I've read, it's not hard to reduce E2, if any, with AI. Tricky is to reduce SHBG, my case

 

[Jed Dorsey]

When my E2 started to rise my Uro had me take OTC DIMM 300 mg daily. I had my doubts but went in for follow up blood work and sure enough it worked!

 

[Craig74]

My estrogen was high and my doctor put me on a low dose AI because he said that high estrogen can irritate the prostate. I did some Googling and found this...

"Estrogens are involved in local cell proliferation and prostate carcinogenesis in a manner analogous, yet different, to that of androgens. In addition, estrogens have also been implicated in the development of prostatic inflammation (Prins et al. 2001, Bianco et al. 2006)."

 

[M.J]

I used to take AI but not anymore and I feel the same.
I don’t think I will ever go back to AI.

 

[Craig74]

I used to take AI but not anymore and I feel the same.
I don’t think I will ever go back to AI.

I don't notice much difference either. The one thing I did notice is that my beard grows like crazy. AIs do stimulate FSH. I guess for some people that would be a bad thing (shaving more) but I've always struggled growing a beard and now I have a pretty impressive one

 

[Bmac]

I don't notice much difference either. The one thing I did notice is that my beard grows like crazy. AIs do stimulate FSH. I guess for some people that would be a bad thing (shaving more) but I've always struggled growing a beard and now I have a pretty impressive one

Sorry just to clarify your saying taking ai’s made your beard grow faster?

 

[Craig74]

Correct. Faster for sure... thicker I think. Seems to be quite a few studies showing that AIs increase FSH.

Aromatase inhibitors in men: effects and therapeutic options - PMC

Aromatase inhibitors effectively delay epiphysial maturation in boys and improve testosterone levels in adult men Therefore, aromatase inhibitors may be used to increase adult height in boys with gonadotropin-independent precocious puberty, ...

www.ncbi.nlm.nih.gov

 

[Cataceous]

Correct. Faster for sure... thicker I think. Seems to be quite a few studies showing that AIs increase FSH.
View attachment 15586

Aromatase inhibitors in men: effects and therapeutic options - PMC

Aromatase inhibitors effectively delay epiphysial maturation in boys and improve testosterone levels in adult men Therefore, aromatase inhibitors may be used to increase adult height in boys with gonadotropin-independent precocious puberty, ...

www.ncbi.nlm.nih.gov

This assertion is problematic on various levels. AIs increase LH and FSH, but this generally won't happen in guys on TRT, as their HPTAs remain suppressed. FSH is not known to have a direct connection to hair growth. There could be a correlation in natural men only insomuch as FSH happens to correlate with LH, testosterone and DHT.

 

[madman]

I don't notice much difference either. The one thing I did notice is that my beard grows like crazy. AIs do stimulate FSH. I guess for some people that would be a bad thing (shaving more) but I've always struggled growing a beard and now I have a pretty impressive one

An increase in beard growth is a result of androgen's effects on the hair follicles.

The density/distribution of hair is determined by genetics.

A common trait among men that use exogenous T is thicker/darker/coarser hair growth which tends to be patchy in areas such as the upper back/lats/shoulders.

Let alone facial/overall body hair tends to grow faster.




post #18

Losing hair on head while on TRT plus anastrozole: Causes?

I am on TRT 100mg/week .25 alanstrozole. I also take Ambien, Antihistamin, melatonin. Does ambien cause hair loss if anyone aware of ? I am losing hair since I got on TRT, slow getiing male pattern baldness. My father was not bald. So its not related to gene. what medication probably causing...

www.excelmale.com

 

[nicknot]

I've never heard of anyone getting cancer from high levels of E2. Think how much higher women levels are.

I don't think that's a good way to think about it. It'd be like saying that a woman doesn't have to worry about T levels 3x the range because "think about how much T men have".

Our respective bodies and brains are meant to function at different hormonal levels, I don't think you can make that comparison.

 

[Vince]

I don't think that's a good way to think about it. It'd be like saying that a woman doesn't have to worry about T levels 3x the range because "think about how much T men have".

Our respective bodies and brains are meant to function at different hormonal levels, I don't think you can make that comparison.

High Estradiol Blood Level in Men: How High is Too High?

I decided to do a video on what the highest levels of estradiol should be for men on testosterone replacement therapy (TRT). There's a lot of confusion on the subject since LabCorp and Quest have very narrow sensitive estradiol test ranges. Those estradiol test ranges were derived mostly from...

www.excelmale.com

 

[Gman86]

For what it’s worth, when I eliminated my AI, my estrogen level rose into the 80s and 90s. There are a lot of threads and experts saying that this is perfectly fine but it just didn’t resonate with me. I take a low-dose AI and try to keep mine under 50. I feel better and look better. I am not in the camp of just letting estrogen run wild.

What dose of ai are u currently taking?

 

[Craig74]

This assertion is problematic on various levels. AIs increase LH and FSH, but this generally won't happen in guys on TRT, as their HPTAs remain suppressed. FSH is not known to have a direct connection to hair growth. There could be a correlation in natural men only insomuch as FSH happens to correlate with LH, testosterone and DHT.

Isn't that how HCG works? It increases LH? Does HCG use a different mechanism?

If FSH doesn't affect hair growth, they should have named it something else

 

[Cataceous]

Isn't that how HCG works? It increases LH? Does HCG use a different mechanism?
...

HCG works as a substitute for LH. Like LH, hCG directly stimulates the testicles, leading to endogenous testosterone production. Thus like TRT, hCG therapy usually suppresses the HPTA, resulting in quite low levels of LH and FSH.

If FSH doesn't affect hair growth, they should have named it something else

The problem is that an ovarian follicle is not a hair follicle. But OFSH is kind of cumbersome as an initialism.