Does Pregnenolone and/or DHEA raise testosterone or estrogen levels?

Gunga · Mar 25, 2020

I’m curious as I have just begun taking 25mgs Pregnenolone from Empower pharmacy daily. I might be crazy but when I started DHEA I think my testosterone levels went up slightly. I’m wondering if I’ll have to lower my daily testosterone injection dose. Any thoughts or personal experience would be welcome. Thanks!!!

Nelson Vergel · Mar 25, 2020

DHEA raised estrogen - Excel Male TRT Forum

So i've been on TRT for about 2 years now. 50mg 2x a week along with 250iu hcg 3x week and 5mg of cialis here and there. TT has always been around 800 and E2 has always been in the low 20's. I get my blood work done every 6 months. Six months ago my doctor suggested adding DHEA to my...

www.excelmale.com

Nelson Vergel · Mar 25, 2020

Dehydroepiandrosterone (DHEA) Supplementation Can Increase Estradiol in Elderly Men

DHEAS was the only hormone significantly negatively correlated to the prevalence of erectile dysfunction among 17 investigated hormones, including testosterone and E2, in the Massachusetts Male Aging Study (60). In addition, Basar et al (61) in a consecutive series of 348 male patients reported...

www.excelmale.com

Nelson Vergel · Mar 25, 2020

Neither one raises testosterone in men.

sammmy · Mar 25, 2020

DHEA for me increased libido and ability to reach orgasm when my testosterone was suppressed due to use of Ostarine or Oxandrolone. In both cases, it did not increase testosterone or free testosterone so its sexual effects are via different mechanisms. When I used Ostarine, DHEA 25-50mg/day increased Estradiol. When I used Oxandrolone, a lower dose DHEA 10mg/day failed to increase Estradiol.

In all cases, do blood tests before deciding it increased anything, instead of relying on how you feel sexually.

Gunga · Mar 25, 2020

Interesting! Thanks gents! I will.

Cataceous · Mar 26, 2020

DHEA: Just What Hormones Does It Change? - Peak Testosterone

There are clearly some significant misconceptions about the hormonal changes that DHEA supplementation actually brings about...

www.peaktestosterone.com

Gunga · Mar 26, 2020

Interesting. It increased Free Testosterone in the study. Ok. And I’m assuming Pregnenolone is an “upstream” hormone that converts a portion to DHEA and Progesterone but Pregnenolone doesn’t convert to estrogen. It’s the downstream effects?

Cataceous · Mar 26, 2020

Gunga said:
... And I’m assuming Pregnenolone is an “upstream” hormone that converts a portion to DHEA and Progesterone but Pregnenolone doesn’t convert to estrogen. It’s the downstream effects?