The doctor who discovered DHEA, Dr. Etienne Emile Baulieu, 94 years old and still active, suggests, for good health and longevity, everyone should take 25 mg, daily, which is what he does. I don't believe he knows something we don't know but for whatever reason(s), some people don't tolerate it and the same applies to pregnenolone and the latter is the grandmother hormone. Perhaps a key is low dosing to mimic endogenous production. Just a thought.I honestly don't feel much of a difference with dhea, I been taking it for years, I actually stopped now. I tried pregnenolone but for whatever reason it makes me more depressed. I tried it several times at different times and it's always the same thing.