Curcumin Improves Delayed Onset Muscle Soreness and Postexercise Lactate Accumulation

madman

Super Moderator
ABSTRACT

The efficacy of curcumin supplementation is traditionally limited due to its poor bioavailability. Despite this, curcumin has previously been shown to improve biomarkers of muscle damage. The addition of a novel drug delivery system that improves bioavailability could improve exercise recovery. The purpose of this randomized double-blind placebo-controlled study was to assess the effect of curcumin (combined with LipiSperse) when consumed as a drink on exercise recovery in recreationally trained healthy males aged 18–35 yrs. The study included 28 young healthy males with strength training experience. The participants undertook lower limb resistance exercise to exhaustion. Fourteen participants received curcumin dispersed in water pre and postexercise and 14 received a matched placebo drink. Pain (visual analogue scale), thigh circumference (TC), lactate, creatine kinase, lactate dehydrogenase, high sensitivity C-reactive protein, myoglobin, interleukin-6, interleukin-10, and tumor necrosis factor-alpha were assessed pre, postexercise and 1, 2, 3, 24, 48, and 72 h postexercise. There was less appearance of postexercise capillary lactate in the curcumin group compared to placebo (7.4 vs 8.8 mmol/L). The placebo group rated overall muscle pain as higher compared to the curcumin group at 48- and 72-h postexercise. TC was reduced in the curcumin group compared to the placebo group at 24- and 48-h postexercise. The results suggest curcumin may facilitate a quicker return to exercise training and/or allow a higher training intensity than a placebo by reducing postexercise pain, modulating inflammatory pathways, and reducing lactate accumulation in an exercising population.








Conclusion

The results suggest that curcumin with added LipiSperse may allow for a quicker return to exercise training, or to exercise at higher thresholds than the placebo drink. This may be due to an interaction between IL-6 and IL-10 eliciting anti-inflammatory properties which reduce TC, pain, and modulate energy metabolism. It is recommended that future studies examine the effects of curcumin in chronic exercise performance for both endurance and resistance-type exercise.
 

Attachments

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Table 1. Participant baseline characteristics and clinical measures, mean ± SD.
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Figure 1. Pain Visual Analogue Scale (mm) in curcumin and placebo groups at all timepoints. “*” denotes the difference between groups, “a” denotes difference from baseline (curcumin), "b" denotes difference from baseline (placebo), “c” denotes difference from postexercise (curcumin), “d” denotes difference from postexercise (placebo) (p < 0.05).
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Figure 2. Thigh circumference (cm)—adjusted means ± SD. “*” denotes significant differences between groups (p < 0.05).
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Figure 3. Capillary lactate (mmol/L)—adjusted means ± SD. “*” denotes significant differences between groups (p < 0.05).
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Curcumin with increased bioavailability

Introducing HydroCurc®, a cold water dispersible (CWD), Curcuma longa extract.

Fat-soluble ingredients have limited solubility in the watery gastrointestinal environment and follow the same pathway of intestinal absorption as other fats that are consumed. Various fat-soluble ingredients, including curcumin, offer numerous benefits to human health. But in the absence of adequate absorption, such benefits cannot be fully realized.

HydroCurc® is a new type of curcumin specifically designed to increase the bioavailability of curcuminoids. In aqueous environments (such as the stomach), the specifically designed

This net effect translates to increased bioavailability. With over 80% curcuminoids, HydroCurc supplies a large amount of curcuminoids in a water-dispersible formulation.




Why Choose HydroCurc?

A recent pharmacokinetic study on HydroCurc in humans aimed to compare the pharmacokinetics of a single dose of a commercially available curcumin product with a curcumin-LipiSperse delivery system.
 

25 Jun 2020 --- Effervescent curcumin will now be available to consumers in the form of Holland & Barrett’s Vitaboost Turmeric. The product contains Pharmako Biotechnologies’ HydroCurc for joint health, as well as vitamin C for immunity-boosting health benefits. This novel format is produced with LipiSperse, which addresses curcumin’s lipophilic nature and aids bioavailability. Vitaboost Turmeric taps into the trend for diversifying delivery formats.




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Question remains if this offsets the adaptive damage and inflammation from exercise - much like dosing antioxidants preWO blunts the ROS and adaptive effects.
 
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