Coronavirus COVID-19 Update: Hydroxychloroquine and Other Treatments

[sokaiya]

Scoop: Bayer to donate potential coronavirus drug to U.S.

I would hope hospitals would have supplies of this drug by next week.

 

[Vince]

From what I hear, they're not sure that Hydroxychloroquine will work or may works for some but not everyone.

 

[Nelson Vergel]

Here is my video of today

 

[Dansk]

Returned to work today after a couple days off.
working with positive patients, one who is 80 and multiple Comorbs. He did receive the anti malaria drug and azithiromycin. and they are looking to discharge him after 2 negative follow up tests. Hearing similar results with other patients. I am also hearing they are giving the cocktail to all positive patients.

 

[Nelson Vergel]

Good video from a PharmD

 

[Loki]

Returned to work today after a couple days off.
working with positive patients, one who is 80 and multiple Comorbs. He did receive the anti malaria drug and azithiromycin. and they are looking to discharge him after 2 negative follow up tests. Hearing similar results with other patients. I am also hearing they are giving the cocktail to all positive patients.

I really feel like there is something to this. We have one white paper study and tons of anecdotal reports. I would love to see some larger studies on this ASAP.

 

[Guided_by_Voices]

- Something that seems very fundamental but which I have not seen anywhere would be a simple correlation between disease trajectory and nutrient status, specifically Vitamin D, Zinc, Vitamins C and A, Selenium, lithium, iodine and magnesium. All of these are part of immune function and many people have been reported to be low in many of these ("low" in comparison to optimal, not minimum levels). LDL cholesterol would be interesting too since it is know to have immune functions. Has anyone seen a high-quality look at this?

- The often-repeated statement that immunity declines in older people may be substantially preventable and/or reversible. For example, melatonin and products of the thymus gland both decline with age and have immune function, but both can be supplemented. Unfortunately, as many here are aware, the NIH/CDC have generally refused to fund studies focused on reducing the affects of aging. Interestingly, the studies and observations showing that elderly with high-LDL live longer could be partially due to immune benefits.

- There are apparently multiple strains of the virus which may have very different characteristics. This could explain some of the wide variation in symptoms being reported, so saying that N number of people will ultimately be exposed to the virus doesn't have much meaning until the different strains are better studied and the protection conferred (or risks) based on various supplement strategies is better understood.

- Also, from what little I know about the near-term "vaccine" calling it a vaccine seems deceptive since it, from what I understand, does not have an adjuvant and may confer cell-mediated immunity (both probably good) but is even less well-understood long-term that normal vaccines (probably bad).

Having a reserve of resilience and good health including optimized nutrient status will likely always be the foundation of a good survival plan.

 

[Nelson Vergel]

 

[Nelson Vergel]

COVID-19 Clinical Trial Launches at University of Minnesota

The University of Minnesota today is launching a clinical trial on a post-exposure treatment for coronavirus COVID-19 disease.

med.umn.edu

 

[Nelson Vergel]

 

[Rock H. Johnson]

I do not know where to place this so I added it here.

[WITHDRAWN: Potential false-positive rate among the 'asymptomatic infected individuals' in close contacts of COVID-19 patients] - PubMed

<span><b>Editor office’s response for Ahead of Print article withdrawn</b> The article “Potential false-positive rate among the ‘asymptomatic infected individuals’ in close contacts of COVID-19 patients” was under strong discussion after pre-published. Questions from the readers mainly focused...

pubmed.ncbi.nlm.nih.gov

 

[Nelson Vergel]

Some previous videos from this series (visit MedCram.com for the full series): -

Coronavirus Pandemic Update 41: Shelter In Place, FDA Investigates Hydroxychloroquine for COVID-19: https://youtu.be/hPz5KxgI_K4 -

Coronavirus Pandemic Update 40: Ibuprofen and COVID-19 (are NSAIDs safe?), trials of HIV medications: https://youtu.be/dT6mHi_8V5E -

Coronavirus Pandemic Update 39: Rapid COVID-19 Spread with Mild or No Symptoms, More on Treatment: https://youtu.be/AToF8O5T86s -

Coronavirus Pandemic Update 38: How Hospitals & Clinics Can Prepare for COVID-19, Global Cases Surge: https://youtu.be/MoisrCTu0SY -

Coronavirus Pandemic Update 37: The ACE-2 Receptor - The Doorway to COVID-19 (ACE Inhibitors & ARBs): https://youtu.be/1vZDVbqRhyM -

Coronavirus Pandemic Update 36: Flatten The COVID-19 Curve, Social Distancing, Hospital Capacities: https://youtu.be/vww1nIIoqmw -

Coronavirus Pandemic Update 35: New Outbreaks & Travel Restrictions, Possible COVID-19 Treatments: https://youtu.be/vE4_LsftNKM -

Coronavirus Epidemic Update 34: US Cases Surge, Chloroquine & Zinc Treatment Combo, Italy Lockdown: https://youtu.be/U7F1cnWup9M -

Coronavirus Epidemic Update 33: COVID-19 Medication Treatment Trials, Global Testing Remains Limited: https://youtu.be/Mm7UrZeu-74 -

Coronavirus Epidemic Update 32: Important Data from South Korea, Can Zinc Help Prevent COVID-19? https://youtu.be/Eeh054-Hx1U -

Coronavirus Epidemic Update 31: Mortality Rate, Cleaning Products, A More/Less Severe Virus Strain? https://youtu.be/7YI2tOoVVpk

 

[Nelson Vergel]

Coronavirus Antibody test

Is it possible to take a test now to see if we have been previously exposed to the corona virus? I know a finger prick test is coming soon but I would like to see if I could check sooner in case of any delays. 6 weeks ago I had an unknown viral infection that started out like strep. I ran a...

www.excelmale.com

 

[jdthoosier]

A friend on the front-lines of this fight indicated that her hospital was looking at pulling antibodies from the plasma of recovered patients and injecting them into the more critical patients to help them fight the virus. If this has been posted elsewhere here, my apologies.

 

[Guided_by_Voices]

I think the general search term for that is "convalescent plasma therapy"

 

[Nelson Vergel]

We are starting to hear that hydroxychloroquine plus Azithromax may not be helping critical patients in ventilators much. We will see what the prevention data show.

 

[Dansk]

Seems to be a timing issue, receiving sooner rather than when your in full respiratory distress may have better outcomes.

 

[MarkLA]

This is was for N=80 to followup on the earlier N=20 study in France.

Interesting, they had cardiologists look at the QT time and excluded people whose heart QTc time made the risk-benefit not worth it. Maybe that will be part of the standard protocol.

https://www.mediterranee-infection.com/wp-content/uploads/2020/03/COVID-IHU-2-1.pdf

 

[Cataceous]

Coronavirus has 'stable genome,' study suggests, so vaccine could help 'over many years'

Currently, there is no known specific medicine to treat the novel coronavirus, but researchers in Italy suggest that the COVID-19 disease is slow to mutate, based on its genetic material. This finding could aid in helping large swaths of people over an extended period of time once a specific...

www.foxnews.com

Article also notes:

New York Gov. Andrew Cuomo announced on Tuesday the state will start coronavirus drug trials, as the hard-hit state recently acquired 70,000 doses of hydroxychloroquine, 10,000 doses of zithromax and 750,000 doses of chloroquine.​

 

[Nelson Vergel]

My friend George Carter put together this summary table of potential COVID-19 treatments with references

POTENTIAL COVID TX

POTENTIAL COVID-19 TREATMENTS (DRAFT) Note Date: March 28, 2020 SEE NEW VERSION HERE: https://docs.google.com/document/d/1XY7yCtjPI8oBbURTYIP_0elhPHolw_BJ53g_VX4_NOQ/edit?usp=sharing ANTIVIRALS...

docs.google.com