Considering Pregnenolone

GreenMachineX · Oct 21, 2019

I’m back to considering pregnenolone since my levels are way below bottom of the range and maybe that’s the source of my sleep issues. I already have low normal cortisol levels, and so my concern is if I respond poorly, could it shutdown natural production of cortisol enough to cause real issues? Or am I looking too deep or in the wrong direction? Can supplementing pregnenolone cause natural levels to plummet even farther and cause other real issues? Thanks in advance.

Vince Carter · Oct 21, 2019

Whichever just start low...5mg...and judge your tolerance for it.

Gman86 · Oct 21, 2019

Here’s a great video talking about pregnenolone and DHEA that might be helpful.

drkelp · Oct 23, 2019

I've had pretty good luck with it. Though it's almost like it raises libido and mood for a week or two then wanes a bit. I'm using Nutricology time release.

GreenMachineX · Oct 23, 2019

What dose?

drkelp · Oct 23, 2019

50mg again time release whatever that's worth. Just my 2 cents your mileage will likely vary.

Deleted member 12831 · Oct 24, 2019

GreenMachineX said:
I’m back to considering pregnenolone since my levels are way below bottom of the range and maybe that’s the source of my sleep issues. I already have low normal cortisol levels, and so my concern is if I respond poorly, could it shutdown natural production of cortisol enough to cause real issues? Or am I looking too deep or in the wrong direction? Can supplementing pregnenolone cause natural levels to plummet even farther and cause other real issues? Thanks in advance.

I don't know what low normal means but if am cortisol is below 15 according to many and the Cleveland clinic you need further testing including provocative testing. If am cortisol is low along with lower acth serum (35 and below) that could indicate Secondary adrenal insufficiency. If it were I would also be testing igf-1 and if I could I would get the metyrapone stim test or the ITT stim test to test for gh deficiency and SAI

DixieWrecked · Nov 4, 2019

Vince Carter said:
Whichever just start low...5mg...and judge your tolerance for it.

This. 10mg is all I need. I love Pregnenolone but too much messes up my sleep big time.

GreenMachineX · Nov 4, 2019

DixieWrecked said:
This. 10mg is all I need. I love Pregnenolone but too much messes up my sleep big time.

Haven’t had the gall to try it yet. But when I work up the courage, that’s all I’ll start with.

TorontoTRT · Nov 6, 2019

How do you guys feel anything from these doses? I take 100 mg Pregnenolone daily with my DHEA but feel nothing. It's slow release.

Vtail · Nov 7, 2019

TorontoTRT said:
How do you guys feel anything from these doses? I take 100 mg Pregnenolone daily with my DHEA but feel nothing. It's slow release.

Same here. I take 50 mg of each at the suggestion of my doc and to make my labs look better. I feel no different with or without.

DixieWrecked · Nov 7, 2019

TorontoTRT said:
How do you guys feel anything from these doses? I take 100 mg Pregnenolone daily with my DHEA but feel nothing. It's slow release.

Not sure, but I definitely feel it. Almost like speed sometimes.

Deleted member 12831 · Nov 29, 2019

Vtail said:
Same here. I take 50 mg of each at the suggestion of my doc and to make my labs look better. I feel no different with or without.

If pregnenolone is low if it were me, I would test the entire adrenal pathway, am cortisol, acth serum, dhea-s, progesterone as well. If adrenal pathway hormones are low, especially dhea-s then that could be a sign of other issues such as adrenal deficiency, sai or pai