Nelson Vergel
Founder, ExcelMale.com
"This study evaluated the efficacy of clomiphene on the treatment of idiopathic PE. Currently, the etiologies of PE are not well understood; but according to possible causes, some traditional treatments for physiological premature ejaculation have been recommended, such as pharmacological management with paroxetine, sertraline, clomipramine, dapoxetine, and local lidocaine cream. Some physical maneuvers are also recommended, such as the squeeze technique, and mental distraction, with varied success rates.
The treatment of premature ejaculation was changed dramatically after the introduction of selective serotonin reuptake inhibitors (SSRIs), as the American Urological Association considered SSRIs as first-line systemic therapy for PE (27). In 1994, paroxetine was the first SSRI to be used for PE (28). From that time onward, most SSRIs such as clomipramine and fluoxetine are used in the treatment of ejaculation delay. Recently, dapoxetine was considered as the first prescription treatment of PE and strongly suggested for use in younger men with primary PE.
Dapoxetine is the latest and most effective SSRI. It is structurally similar to fluoxetine, so naturally, being an SSRI, it will have some drawbacks related to the nature of SSRIs. In particular, it induces or worsens existing ED, for which most researchers usually recommend the use of phosphodiesterase type 5 inhibitors in combination with this drug in PE patients (6, 29, 30).However, patients who have taken SSRIs for various reasons may experience acute and long-term side effects other than decreased sex drive, dry mouth, nausea, headache, diarrhea, anxiety, restlessness, sweating, weight gain, sleepiness, or fatigue, which sometimes cause treatment discontinuation (31)."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630386/
