It’s been almost a year since I started taking 400mg of pregnenolone a day in the morning on an empty stomach. I’ve tried different brands but settled on the Double Wood brand from Amazon for the price and effectiveness. Had a brief time where I tried stopping here and there and didn’t feel as good, so I just went back, but it’s mostly been 400mg a day for nearing a year.
Before all these, my pregnenolone blood test was somewhere around 23. On 100mg, at Quest labs it came out at 73. After a almost year on 400mg, from Labcorp, it came back at 104. This is all in ng/dL.
The rest of my protocol’s varied a bit, but the core of it during the last two tests was 24mg of test-c daily, 720iu’s HCG 3x a week, HGH peptides in the evening 5x a week, and various thyroid med combinations. More HCG didn’t seem to have any significant impact on my pregnenolone levels during tests compared to smaller amounts, though I do still feel better on that amount in ways similar to taking pregnenolone.
I tend to have low cortisol and have extensive experience replacing it and trying different things for related hormones, which include hydrocortisone, cortisone acetate, fludrocortisone, rhodiola, adrenal cortex, and pretty much anything you can throw at it. I’ve done transdermal pregnenolone, progesterone, you name it. My thyroid levels also tend to come back low, so I’ve done anything you could think of with NDT, T4, and T3 in their various formats. For me, pregnenolone does raise my resting heart rate in a dose dependent manner, about 1bpm per 100mg. Goes up and down accordingly any time I made a change there. Blood pressure didn’t change much. Does cause a bit of water retention in my stomach and legs and lower back, maybe a bit on the face too. Raises my libido a lot when on thyroid meds. Also helps give me the ability to sweat in response to things, which I lack without it unfortunately.
Comparing things, I get a lot of the benefits from replacing cortisol with cortisone acetate but without the sides. Not all, but many. We’ll find out how much it affected my morning cortisol because that test isn’t back yet, but on the last tests it didn’t really seem to help there. The biggest benefit for me is likely one that I saw in one study, which saw a dose dependent increase in dopamine in response to different things when supplementing pregnenolone. My latest experiments with Selegiline at 2.5mg a day under the tongue in the morning seem to confirm that, which works synergistically with it.
Seems like when you supplement pregnenolone, your body is going to preferentially convert it to things and try to use it up over increasing your stores of it. At least in my case. I came into all this with PFS, so the allopregnenolone conversion likely benefits me a lot. Sucks that my blood test scores on it seem to have a cap, but I do get the benefits of it, so I’m not too sad about that. Main downside for me is that it’s technically one of the priciest things I do to take that much of it. 200mg a day was acceptable, but 400mg for me is where I prefer to be in terms of mental wellbeing and libido and being able to sweat and be more normal after PFS.
Extremely synergistic with T3 / liothyronine. If I’m on preg with little hits of that throughout the day, in as little as 18.75mcg of T3 or up to 30-40mcg T3 a day, and I have a good base of T4 built up, I think about sex pretty much all day and my dick might even get too hard. I do microdose cialis daily at 2.5-10mg, but it doesn’t do anything if I don’t have everything else in place because I can’t feel my penis as much for the blood flow to happen. I’m taking more cialis now because I had to get some weird amino version and it seems like it’s half as effective so I take more, and it was getting to be annoying cutting the pills that small.
For libido and mental well being, if my thyroid levels are looking good, pregnenolone has been one of the most effective things in my protocol. Add in some selegiline, and at least mentally I feel great. So great it takes some getting used to because I can get caught up in pretty much anything if I’m not careful. Even without the selegiline, however, things were great on most fronts, sans glycogen retention and dehydration, which I still struggle with.
Feel free to ask any questions and over time I’ll do my best to answer them because a lot of people over time have asked me about this.
Before all these, my pregnenolone blood test was somewhere around 23. On 100mg, at Quest labs it came out at 73. After a almost year on 400mg, from Labcorp, it came back at 104. This is all in ng/dL.
The rest of my protocol’s varied a bit, but the core of it during the last two tests was 24mg of test-c daily, 720iu’s HCG 3x a week, HGH peptides in the evening 5x a week, and various thyroid med combinations. More HCG didn’t seem to have any significant impact on my pregnenolone levels during tests compared to smaller amounts, though I do still feel better on that amount in ways similar to taking pregnenolone.
I tend to have low cortisol and have extensive experience replacing it and trying different things for related hormones, which include hydrocortisone, cortisone acetate, fludrocortisone, rhodiola, adrenal cortex, and pretty much anything you can throw at it. I’ve done transdermal pregnenolone, progesterone, you name it. My thyroid levels also tend to come back low, so I’ve done anything you could think of with NDT, T4, and T3 in their various formats. For me, pregnenolone does raise my resting heart rate in a dose dependent manner, about 1bpm per 100mg. Goes up and down accordingly any time I made a change there. Blood pressure didn’t change much. Does cause a bit of water retention in my stomach and legs and lower back, maybe a bit on the face too. Raises my libido a lot when on thyroid meds. Also helps give me the ability to sweat in response to things, which I lack without it unfortunately.
Comparing things, I get a lot of the benefits from replacing cortisol with cortisone acetate but without the sides. Not all, but many. We’ll find out how much it affected my morning cortisol because that test isn’t back yet, but on the last tests it didn’t really seem to help there. The biggest benefit for me is likely one that I saw in one study, which saw a dose dependent increase in dopamine in response to different things when supplementing pregnenolone. My latest experiments with Selegiline at 2.5mg a day under the tongue in the morning seem to confirm that, which works synergistically with it.
Seems like when you supplement pregnenolone, your body is going to preferentially convert it to things and try to use it up over increasing your stores of it. At least in my case. I came into all this with PFS, so the allopregnenolone conversion likely benefits me a lot. Sucks that my blood test scores on it seem to have a cap, but I do get the benefits of it, so I’m not too sad about that. Main downside for me is that it’s technically one of the priciest things I do to take that much of it. 200mg a day was acceptable, but 400mg for me is where I prefer to be in terms of mental wellbeing and libido and being able to sweat and be more normal after PFS.
Extremely synergistic with T3 / liothyronine. If I’m on preg with little hits of that throughout the day, in as little as 18.75mcg of T3 or up to 30-40mcg T3 a day, and I have a good base of T4 built up, I think about sex pretty much all day and my dick might even get too hard. I do microdose cialis daily at 2.5-10mg, but it doesn’t do anything if I don’t have everything else in place because I can’t feel my penis as much for the blood flow to happen. I’m taking more cialis now because I had to get some weird amino version and it seems like it’s half as effective so I take more, and it was getting to be annoying cutting the pills that small.
For libido and mental well being, if my thyroid levels are looking good, pregnenolone has been one of the most effective things in my protocol. Add in some selegiline, and at least mentally I feel great. So great it takes some getting used to because I can get caught up in pretty much anything if I’m not careful. Even without the selegiline, however, things were great on most fronts, sans glycogen retention and dehydration, which I still struggle with.
Feel free to ask any questions and over time I’ll do my best to answer them because a lot of people over time have asked me about this.
