Association of serum uric acid with male sexual hormones and erectile dysfunction

[Nelson Vergel]

This study investigates the causal relationship between uric acid test values and male sexual hormones, including testosterone, sex hormone-binding globulin (SHBG), estradiol (E2), and erectile dysfunction (ED) using a bidirectional two-sample Mendelian randomization analysis.
Key Findings:

1. Uric Acid and Hormones:
   • Elevated uric acid test values are associated with lower SHBG and testosterone levels, suggesting that higher uric acid may negatively affect these hormones.
   • SHBG significantly mediates the relationship between uric acid test values and testosterone, accounting for 98.1% of the effect.
   • There is no significant causal effect of uric acid test values on E2, FSH (follicle-stimulating hormone), or LH (luteinizing hormone). However, reverse analysis shows that higher SHBG and E2 levels can reduce uric acid levels.
2. Uric Acid and Erectile Dysfunction (ED):
   • Elevated uric acid test values show a positive association with an increased risk of ED, but this association disappears after adjusting for confounding factors.
   • The study suggests that the relationship between uric acid test values and ED might be complex and influenced by other factors.

Clinical Implications:

• The study emphasizes the importance of monitoring uric acid test values and E2 levels in men, particularly those with hypogonadism and ED, as they can significantly impact testosterone levels and overall sexual health.

Strengths and Limitations:

• The study is novel in using genetic data to establish a causal relationship between uric acid test values and male sexual hormones, overcoming biases common in observational studies.
• However, the findings are limited to populations of European ancestry, and potential confounders might influence the results.

Conclusion:The study provides genetic evidence that elevated uric acid test values negatively affect SHBG and testosterone levels, which could have implications for male sexual health. Further research is needed to explore the relationship between uric acid test values and ED, especially in diverse populations.

Association of serum uric acid with male sexual hormones and erectile dysfunction: a bidirectional 2-sample Mendelian randomization analysis

AbstractBackground. Observational studies indicated that serum uric acid (SUA) was associated with male sexual hormones and erectile dysfunction (ED). Howe

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