madman
Super Moderator
You would mean liver.
When it comes to testosterone therapy methyltestosterone was the older original c-17 alpha alkylated oral formulation used which had been linked to such!
It is no longer used and was replaced by Andriol (oral TU) which bypasses the liver.
More recently there are 3 new oral TU formulations (Jatenzo, Tlando and Kyzatrex) which are much more effective then the older outdated Andriol testocaps and also pose no liver toxicity.
* [1]. Systemic delivery of oral TU occurs instantly (>97%) via the intestinal lymphatic system thus bypassing the liver completely.
Liver toxicity would be related to any of the c-17 alpha orals.
The use of exogenous T for testosterone replacement in men whether in the form of intranasal (Natesto®), patch, pellets, oral (Jatenzo®, Tlando®, Kyzatrex® ), buccal, transdermal (gel/cream), injectable (short, medium, or long-acting, mixed esters) does not cause any harm to the liver/kidneys.
It would be the use of AAS 17α-alkylated orals such as stanozolol, oxandrolone, methyltestosterone, methandrostenolone, oxymetholone, and fluoxymesterone as they are notorious for driving down HDL, increasing LDL, stressing the liver and hammering down SHBG.
Even then the dose/duration of use will play a big role.
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