Anastrozole - Stabilization

[TDM812]

I have been struggling with estrogen problems for over a year. I just can’t seem to get dialed in. I was at .1 anastrozole every 3 days, and after 19 days I went high, so I adjusted to .1 every other day. That brought me down to normal after a few days, then a little low, and now high after 15 days.

Questions:

What is the stabilization time for Anastrozole?

What do you recommend for my next adjustment?

Side notes:

I take 140mg cypionate split between 2 does weekly.

My Anastrozole capsules are .1, and compounded at a legit pharmacy.

 

[TDM812]

I have been struggling with estrogen problems for over a year. I just can’t seem to get dialed in. I was at .1 anastrozole every 3 days, and after 19 days I went high, so I adjusted to .1 every other day. That brought me down to normal after a few days, then a little low, and now high after 15 days.

Questions:

What is the stabilization time for Anastrozole?

What do you recommend for my next adjustment?

Side notes:

I take 140mg cypionate split between 2 does weekly.

My Anastrozole capsules are .1, and compounded at a legit pharmacy.

No labs - I’ve gotten pretty good at identifying high/low e2.

 

[Vince]

By taking the AI 24 hours after injection both drugs are peaking which is an ideal for controlling E2

 

[TDM812]

By taking the AI 24 hours after injection both drugs are peaking which is an ideal for controlling E2

Thank you, for the insight. What do you make of me going high after 15 days? What do you think my next adjustment should be?

 

[Vince]

Thank you, for the insight. What do you make of me going high after 15 days? What do you think my next adjustment should be?

I would stay on your protocol for 6 weeks and then take labs. It's the only way you're going to properly adjust your meds.

 

[TDM812]

I would stay on your protocol for 6 weeks and then take labs. It's the only way you're going to properly adjust your meds.

Even if I already went too high?

 

[Cataceous]

...
What is the stabilization time for Anastrozole?

What do you recommend for my next adjustment?
...My Anastrozole capsules are .1, and compounded at a legit pharmacy.

The half-life of anastrozole is about 50 hours, so figure 8-10 days to stabilize. This half-life is a half to a third or less that of T cypionate, so at least in theory it's not easy to keep the relative levels in synch with two doses a week—though Vince's suggestion might help. There is an advantage in self-compounding, in that you can create smaller doses to take more frequently and better align the serum levels.

 

[Vince Carter]

That makes little sense to what you're doing with your dose and EOD. ANy use of DHEA/Prog/Preg? HCG dose/timing?

hat brought me down to normal after a few days, then a little low, and now high after 15 days.

 

[TDM812]

That makes little sense to what you're doing with your dose and EOD. ANy use of DHEA/Prog/Preg? HCG dose/timing?

I’ve not tried anything of those medications. What would recommend as a protocol, given the information provided?

 

[Vince Carter]

No labs - I’ve gotten pretty good at identifying high/low e2.

I don't think you're as good at that as you think you are, needs labs, stability, etc etc

 

[CoastWatcher]

No labs - I’ve gotten pretty good at identifying high/low e2.

You’ll never be as good at making that call as a lab test will be. Take the guess-work out of this and test on a consistent basis.

 

[Tman]

No labs - I’ve gotten pretty good at identifying high/low e2.

Actually, the doc confirmed the AI peaks in about an hour if you are using Empower's compounded AI.

 

[TDM812]

Actually, the doc confirmed the AI peaks in about an hour if you are using Empower's compounded AI.

It’s not Empower’s, but it’s brand name Anastrozole compounded into .1mg gel capsules.