Amphetamines, Alcohol & Testosterone

[Mikey1970]

Hi guys, I dunno if this info will help anyone but I've decided to put it up in case it might.

My endo told me that the cause of my low testosterone is because of chronic use of the amphetamine speed in my younger days.

Speed shrinks the penis and halts the production of testosterone, and even after a person stops taking speed, the testes continues to produce very little testosterone.

I hope this info may help someone

 

[PAUL-E]

Thanks I learned something new. Opioids can do this as well!

 

[Vince]

don't forget alcohol

 

[waltkowalski]

Interesting, seems most users on this forum don't drink. I understand that alchohol kind of undoes what we are trying to do with TRT but is any amount tolerable? A few beers on Saturday night?

Any risk of serious damage to being on TRT and light drinking?

 

[Nelson Vergel]

waltkowalski

Two beers or glasses of wine every few days will not affect testosterone but MAY increase triglycerides and fat deposition. Having said that, the stress reducing effects of a small alcohol consumption is good for the heart and general quality of life.

I only drink Patron Silver tequila once every two weeks (two drinks) on the rocks since it seems not to slow me down the day after at the gym. Beer and wine kill me.

Here is an interesting paper on alcohol and fertility

http://pubs.niaaa.nih.gov/publications/arh22-3/195.pdf

Habitual alcohol consumption associated with reduced semen quality and hormones

 

[Nelson Vergel]

Back to the amphetamine question. This is the only reference I found but it is an animal study.


Br J Pharmacol. 1996 Jun; 118(4): 984–988.


PMCID: PMC1909523




Inhibition by amphetamine of testosterone secretion through a mechanism involving an increase of cyclic AMP production in rat testes.
[h=2]Abstract[/b]1. The effect of amphetamine on the secretion of testosterone and the production of testicular adenosine 3':5'-cyclic monophosphate (cyclic AMP) in rats was studied. 2. A single intravenous injection of amphetamine decreased the basal and human chorionic gonadotropin (hCG)-stimulated levels of plasma testosterone. Plasma LH levels were not altered by the injection of amphetamine. 3. Administration of amphetamine in vitro resulted in a dose-dependent inhibition of both basal and hCG-stimulated release of testosterone. 4. Amphetamine enhanced the basal and hCG-increased levels of cyclic AMP accumulation in vitro in rat testes. 5. These results suggest that amphetamine inhibits the spontaneous and hCG-stimulated secretion of testosterone from the testes through a mechanism involving an increase in cyclic AMP production.

 

[Vitamin_C]

Beer and wine kill me as well. Nelson, how much tequila do you use in your two drinks on the rocks?

 

[Vince]

Dealcoholized Red Wine Decreases Systolic and Diastolic Blood Pressure and Increases Plasma Nitric Oxide
(and red wine with alcohol does not)
http://circres.ahajournals.org/content/early/2012/09/06/CIRCRESAHA.112.275636.abstract