Nebido every 3 months also increased my hematocrit, I had testicular atrophy and some symptoms of prostatic hyperplasia, but I was able to resist the symptoms. With the change in protocol and ester, I was surprised how such a small dose could cause a hematocrit and blood pressure to rise so rapidly. You have to wait a little and start even more slowly. Thank you.The answer to your question is yes, even a few mg change will force your body to re-adapt and throw hormones into a state of flux.
Nebido isn't any different, but reaching a stable state takes much longer, so changes can be very gradual whereas cypionate changes happen faster and can be more noticeable since the half-life is shorter.