estradiol

Hello everybody, Have been doing some reading some reading thru archives about SHBG. Going over my blood results in the past 10 years, I noticed I always had very low SHBG. In my last bloodwork, it was around 14 and that was with a High Free Androgen Index (121.8, ref: 14-95) Testosterone was...

so I been doing this for couple days now. my typical Tprop dosing (lowered to currently 20mg/day) + 10mg Masteron propionate. I will give it couple weeks and do blood work +e2 sensitive. initial effects on mood/libido are very good. my e2 tends to run on the high side, 50-60 pg/ml. according to...

Hey everyone, I have been on 100mg of Testosterone Cypionate & 750 iu hCG for 8 weeks. My subcutaneous injection schedule is as follows: 20mg Test C - Monday, Wednesday, Friday, Saturday & Sunday 250 iu hCG - Tuesday, Thursday and Sunday I have never had acne this bad before. My back and...

I first started TRT with far too much for far too long 250mg of T Cyp/week. None of my symptoms (crippling fatigue, very low libido etc. improved) Browsing through the internet, I even tried Aromatase inhibitors incase high E conversion was preventing benefits, but that didn't work. When I...

The role of testosterone, the androgen receptor, and hypothalamic-pituitary–gonadal axis in depression in ageing Men https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789012/ Best review on this topic I have seen so far. Might be also very interesting for non-depressed ageing and young men. "In...

Been on TRT for about 2 years @ 40mg twice per week. Recent bloodwork *(yesterday) shows my estradiol has risen to 54pg/mL (was 40).. At what point will my urologist introduce an AI? Or, is it symptom based? Or, is 54 no big deal?

I am on the old Dr Crisler protocol: I do .25cc of HCG on day 1 and 2, and 0.5cc (100mg) injection of Test cypionate on day 3. It works well for me. The problem is on day 7 my T level is 580 which is OK for me, but my estradiol is 42. Any suggestions greatly appreciated. Many thanks for...

I'm wondering if anyone has experiences or data on the effect of different levels of body fat on aromatization. Right now I'm 18-19% body fat, and I'm wondering if I drop to 10-12% how much that will reduce my E2 if I kept my TRT dose constant. For example, if I drop from 19 to 11% body fat...

I saw this featured on Dr Thomas O'Connor's IG page the other day, and thought it was interesting - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11167061/

I always thought that estrogen helps the liver produce more IGF-1, however, was just researching the connection real quick on google, and it seems like everything states that increasing estrogen actually inhibits the liver from making IGF-1. So a person would actually want lower estrogen levels...

Gentlemen, there is a cure for Low SHBG FINALLY. And, It is tangible unlike the "keto diet and fasting". There is a newly approved drug that could easily more than double our SHBG and for many of us would mean a new life and TRT working. The drug is called Rezdiffra (Resmetirom) manufactured by...

Hi there I posted a few months ago and took the advice to lower my dosages - thanks to those who advised. Currently on Sustanon, HCG and Anastrazole. This message isn't to have a debate on whether or not AIs are good or bad - we're all different and I understand that @Nelson Vergel doesn't want...

Not sure what thread to put this under— I have gained about 51 pounds since 2018 of mostly abdominal fat. I have noticed at a higher weight, I am not feeling as though my TRT is working long enough. I’m guessing it is getting converted into E2 and/or not hitting the receptor sites as my Free T...

I've finally gotten my results back and here they are (3 mth f/u): TT - 990 (MS) FT - 178 (Dialysis) Estradiol - 44 (LC/MS) Free T3 - 3.2 SHBG - 37 Hematocrit - 54 Hemoglobin - 17.2 LH - <0.2 Reference Range: 1.5-9.3 mIU/mL I'm feeling great and I would not change anything in my protocol...

Hi guys, I find myself outside the US and wanted to check on my estradiol, I can only find an Estradiol ECLIA test here in Italy. I suspect my E2 is gong down. Would this test methodology give me an understanding if my E2 is on the low side, or it would be just better to get back in the US for...

Hi guys, I have couple of questions about my TRT protocol. 1) In my last labs, SHBG came back low (1 unit below normal range). What effect does that have on things like libido, EQ, etc.? Is it necessary to raise it? 2) Unrelated to #1... from time to time my estradiol has been high. Doctor...

ABSTRACT Objectives Accuracy of estradiol measurements is important but conventional proficiency testing (PT) cannot assess accuracy when possibly non-commutable samples are used and method peer-group means are the targets. Accuracy-based assessment of estradiol measurements is needed...

Hello all, I was previously on 90 mg/week, divided in 3 weekly doses of 30 mg, M-W-F, IM on the deltoids. After 6 weeks on this protocol, the labs indicated: Total T: 1044 ng/dL Free T: 19.52 ng/dl Estradiol sensitive: 34 pg/mL SHBG: 36 nmol/L However, I had the following sides effects: -...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016457/ "These analyses were not prespecified and need confirmation in additional studies of other datasets. Our models were modestly predictive, with r-squared values ranging from 0.16 for HDL cholesterol to 0.27 for vBMD, indicating that there...

I've been on TRT for about 10 years. Every time I read the benefits I realize I've never really experienced them. I wondered if I'm on the right dose. It never helped with depression so I take Wellbutrin. I'm 65 yrs old. I was on 0.7 ml but I started to have some problems. I didn't feel great...

Hi there. I’ve been in trt for a year using gels two pumps daily. Also was using hcg twice a week. My challenge is that my E2 levels are really high compared to where I started and although they are not in the clinical danger zone I do find I’m having some issues ie no erections, feeling...

Hey there! I've been on TRT for a while due to secondary hypogonadism. Due to moving / no job, I was off TRT for 2-3 years and my levels dropped to "normal" which for me is <200 total T. Started seeing a new PCP last year who ran 2 morning T tests, both came back low, so he started me on...

Hello, I am 35 175lbs 5’11 and have been on TRT for 2 years. I have been trying to find my sweet spot and get dialed in the majority of the 2 years. I work out 6 days a week and eat very healthy etc…My current issues are: Back acne Oily face Low libido Testes and penis always feel cold and have...

Estradiol: 64.2. (since this result, I started taking arimidex .5 mg (1/2. tablet) twice per week Testosterone total: 1,190 Testosterone free: 25.6 What is the best range for best results? I know the estrogen was too high...

I know everyone is different, but I would like to hear what you have found best for inj frequency, My SHBG is mid range at 45, E2 runs a bit high at 60, HCT and HGB has been a problem for me, last blood work it was 57 and 19 so I did go donate, in the past I have had issues when i donated 3...

Do you inject less than 50 mg of T per week? If so, how do you feel? What were/is your lab results before/after you started TRT? I am on 60 mg with high FT, T and E2. I am considering 50 mg, or even less. I'm on Enathate.

So this relates to all forums, Reddit, various YouTube videos from doctors, pretty much every internet information source. As of the past few years all the rage and focus is on FT. So much so that certain tests are referred to with derogatory names. “Piss poor”. That’s how important FT is to...

I am seeing my endocrinologist tomorrow, curious for initial recommendations as to correct course of action to feel better, low estradiol symptoms.... I had thought of asking about HCG, or estradiol supplementation. Thank you for the help.

Hello All, My name is Steve. I started TRT about 5 months ago and am trying to wrap my head around what my most recent blood testing results are telling me. First of all I am 33, have struggled with my weight for most of my adult life. I would be categorized as obese. I am 6' 2", currently 320...

Hello, I started TRT 11 weeks ago. My protocol is 35 mg of T Enanthate twice a week (Wednesday evening and Sunday morning). Initially I felt quite fine and even libido came earlier than expected (in 4 weeks). My lab results after 6 weeks (a few hours before next injection) were as follows: FT...

I had what I believe to be serotonin syndrome, something I wouldn't wish on my own worst enemy, in December of 2021. It took me two months to feel normal, going through brain fog, brain zaps similar to those coming off antidepressant, blurry vision, anhedonia, exhaustion, panic attacks etc. By...