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  1. Gianluca

    T3 and muscle loss

    also, when you running low on T3, the body will secrete more cortisol/adrenaline to compensate, that its self cause muscle loss
  2. Gianluca

    High testosterone is like … finasteride? Say what!

    At this point the blend Propionate/CYP or ENA to take daily, may be probably the best physiological option to get test into circulation considering metabolites conversion with some daily fluctuation in T, without letting testosterone dropping too low a couple of times in 24hr like the orals do...
  3. Gianluca

    High testosterone is like … finasteride? Say what!

    @Vince Are you still injecting everyday IM?
  4. Gianluca

    High testosterone is like … finasteride? Say what!

    as far as pharmacokinetics, if I remember correctly, scrotal cream applied once per day only is the closet to mimic endogenous T production. Too bad the DHT issue classify it far away from physiologic to me.
  5. Gianluca

    has anyone tried Progest-E for progesterone?

    it doesn't raise serum levels, but it works. Less anxiety/stress and my skin looks better
  6. Gianluca

    Kyzatrex or Jatenzo

    I have been thinking about giving this a try, but I was looking at the inactive ingredients in both, and they sound pretty nasty.
  7. Gianluca

    High testosterone is like … finasteride? Say what!

    This is what has been in my mind for the past few months. I think the issue with the scrotal cream is the unphysiologic conversion of T into DHT, I’m not sure what the general thought is now about the DHT. I would think an oral like Jatenzo would be the most physiological way to get Test into...
  8. Gianluca

    High testosterone is like … finasteride? Say what!

    I remember commenting on this particular study here in the forum, this to be a concern for Progesterone not converting as much into allopregnenolone. Also, this study shows where the max physiological level of T are at about.
  9. Gianluca

    Results: SubQ vs IM @ 70mg/week

    I think the Jatenzo/Kyzatrek overall are the closet to physiological we have, where do you get yours and how much monthly do you pay? I have been thinking to try it for a while now
  10. Gianluca

    Compounded Pregnenolone cap BUD

    I have some Preg capsule at home from Empower, BUD was 05-2023. I'm wondering if potency is still ok or it has been lost substantially, what do you guys think? toss it?
  11. Gianluca

    Help determining proper pregnenolone dosage and frequency

    What Preg product are you using right now?
  12. Gianluca

    Testosterone Cypionate vs Enanthate Ester break down

    an update on my Hikma Test E trial vs Test CYP from empower. Levels are about the same, a bit less on the Hikma, Testosterone speaking I feel the same, I believe my head feels a bit more clear/natural on the Hikma. I think it is a good idea trying not to inject benzyl benzoate, some negative...
  13. Gianluca

    Scrotal Pregnenolone/DHEA to raise androgen levels

    Not much of my intellect, really. You are bringing up good points. Though, oral steroids like DHEA and Pregnenolone, when going through the first pass metabolism get converted into different metabolites, I wouldn’t be surprised if scrotal application of the same steroids would produce a...
  14. Gianluca

    Scrotal Pregnenolone/DHEA to raise androgen levels

    I should have mentioned to read the first post on the thread if interested, Hopefully that won’t be too gibberish for your level of intellect.
  15. Gianluca

    Scrotal Pregnenolone/DHEA to raise androgen levels

    I'm not sure this has ever discussed here, but I found some very interesting data posted and commented by Georgi Dinkov AKA Haidut on the RayPeat forum, how applying Pregnenolone and DHEA (in DSMO) on the scrotum, can raise serum androgens like T DHT and Androsterone, this because directly...
  16. Gianluca

    TRT Effect on 5 Alpha Reductase and Upstream Hormones- Cause of Low Mood and Anxiety?

    I believe if someone is not using huge amount of test for prolonged time, I think probably there is not much to be concerned about the 5-ar. Lower levels of Progesteonre/Pregnenolone can be an issue for some
  17. Gianluca

    Injectable Progesterone SC may not be the best route of administration

    I don’t have the side effects I was experiencing with the injectable. This, as soon as I take it, it really feels calming and soon after when I go to bed I really lay down very still in bed, it is the first Pro I’m using that help me to get to sleep. Some good and bad side effects during the...
  18. Gianluca

    Injectable Progesterone SC may not be the best route of administration

    I don’t think so. Prog in vitamin E, especially when applied to the gums, will bypass first pass in the liver, like an injection. Pro itself has a very short half life in the blood though, but I heard Georgi Dinkov and Mercola saying that because Vit E has about 44hr half life, Pro when...
  19. Gianluca

    Injectable Progesterone SC may not be the best route of administration

    Quick update on the Progesterone dissolved in Vitamin E trial. two weeks after applying a drop (3mg) on my gums, it did not raise my Progesterone serum. However, I do feel it.
  20. Gianluca

    Injectable Progesterone SC may not be the best route of administration

    @Jim Marlowe have you ever tried the StressNon from Idealabs, the Pregnenolone dissolved in DMSO?
  21. Gianluca

    Injectable Progesterone SC may not be the best route of administration

    and here Cataceous comes as usual with some unbiased, fair and articulate comment backed up with actual science, I much appreciate you. To add to your comment, even while on ketosis, the brain and some other tissues, still require some glucose. In fact, I would think ketones as brain glucose...
  22. Gianluca

    Injectable Progesterone SC may not be the best route of administration

    it sounds like you have some solid biology here to argue with Ray Peat, too bad he is not longer with us.
  23. Gianluca

    Injectable Progesterone SC may not be the best route of administration

    What were the vitamin E dosages you recall he was recommending? As far as thyroid, I don’t think he ever recommended high doses of thyroid hormone. He based his thyroid work on Broda Barnes, who would pay attention to body temperature, heart rate and paid attention to TSH, which I do not think...
  24. Gianluca

    Injectable Progesterone SC may not be the best route of administration

    O I found in his work some "little personal discoveries" I found by digging in the medical literature my self, even before even stumbling into his work. It made me to connect some dots about health, that Peat put together many years ago already. Example of his work the importance of burning...
  25. Gianluca

    Injectable Progesterone SC may not be the best route of administration

    I have been doing the same since Monday, after about 30/45min I feel super relaxed. Some people also put the drops on the tongue then massage into the gums. I’m starting to think this is really the best way to get Progesterone in, I’ll do some labs in a week or so
  26. Gianluca

    Injectable Progesterone SC may not be the best route of administration

    I saw this video before. If I had learned about Ray Peat earlier, I would have probably saved allot of time. But when years ago I was exposed to his work, I thought he was a lunatic!
  27. Gianluca

    Injectable Progesterone SC may not be the best route of administration

    @Jim Marlowe how do you apply your drop of Progesterone on the gums? do you use just a finger and massage it in?
  28. Gianluca

    Considering Westward Test E

    One day I swear I will read all.
  29. Gianluca

    Injectable Progesterone SC may not be the best route of administration

    currently comparing these two products: https://healthnatura.com/simply-progesterone-1-08-oz/ https://shop.forefronthealth.com/collections/all/products/molecular-progesterone-supplement
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