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Obviously you're not familiar with longevity research. The effect of diet on longevity is poorly understood. While there is likely an effect, what approach to diet will improve longevity is not known. The research on exercise is definitive. It improves lifespan in virtually every study that...

This is just a nonsense regulation promulgated by the government that does more harm (higher cost) than good. 10 ml vials being used for months/years was standard practice for decades without any problems. My guess is that pharma companies used the theoretical risk of contamination of some...

While I'm all for self-experimentation, I think we can all agree this guy is an idiot. Doing a thousand things all at once, even if he finds something that does extend lifespan, he'll never know which intervention it was. More likely he's shortening his lifespan. As to what works for life...

Sort of. The FDA came out with a directive that vials shouldn't be used past 30 days after the initial puncture. So all the big pharmacy chains made it policy to replace 10ml vials with 1ml if the Rx as written would result in the 10ml vial lasting more than 30 days. Of course to use a 10ml...

SHBG is partially regulated by insulin levels. Low average insulin, high SHBG. High average insulin, low SHBG. There's still a lot of genetic variation of SHBG between individuals and other things can affect levels, but go from high to low insulin and most will see a sizable increase in SHBG...

You clearly need a new physician. Anyone treating someone of your age without concern for your fertility is committing malpractice. I would look for a urologist that specializes in treating hypogonadism and infertility. You may need to travel in order to see someone that has the required...

I agree with the above. Several things jump out in your labs. In addition to the points already made, your SHBG is fairly high, so your free estradiol is likely low. GIven your low aromatization, I would also want to see DHT tested to try and get a more complete picture. Also, your TSH is...

I'm not surprised that the Chinese aren't making it, given that it isn't a simple peptide. It's unlikely that it will ever be approved by the FDA. No one wants to put a $1B up for the trial they want, for what will ultimately be a political decision for approval. There's enough data to know...

No it doesn't. So according to your standard then Metformin isn't safe or effective. Trials get cancelled for lots of reasons. Usually for a lack of funding. Remember BPC-157 can't be patented, so no pharma company is going to pursue doing any research with it.

Not surprised that your doc isn't supportive as it's not FDA approved. For the US source, I've never bought from them, but they probably won't sell to an individual as their market is academia and biotech labs. You would probably need to setup an LLC and a mailbox at a UPS store or similar...

This gets back to how much risk is too much risk. It's a judgement call. Hence, whatever number is picked, even if it's done by an "expert" is still that. It's their individual opinion of what is too much risk.

This is a great example of the genetic varability of risk from elevated HCT that I was talking about. Those who have lived at high elevations for generations develop genetic adaptations and don't suffer adverse effects from the elevated HCT. Of course, those of us whose ancestors lived at sea...

One other point to make, risk at given HCT varies by person. Age and genetics both affect how much risk a particular HCT presents. While 54% is generally viewed as a threshold one shouldn't go over (due to exponentially increasing risk above 54%), the risk of a 54% HCT at the age of 25 is not...

Defensive medicine unfortunately has become standard practice. If he doesn't make that recommendation he risks loosing his license if he's ever investigated by the medical board. Of course a HCT that low for BigTex would only be acheivable off TRT or with weekly blood donations.

I would caution anyone against trying to lower their hematocrit, just for labwork. You really want to know what your day to day hematocrit is. If you chug 2 gallons of water everyday, that's fine, but don't change things for the labwork. Being at 52 for a few hours when in reality your at 55...

I'm waiting for the day when standard of care for depression is: Go outside on a sunny day Run 4 or 5 sprint accelerations repeat every few days if this doesn't work then if you're male Rx Testosterone

I wouldn't base the decision to use anastrozole on an increasing hematocrit. If you're having high estrogen symptoms, then yes. Also nothing says you have to take 1/2 mg. Take only how ever much you need to eliminate symptoms. 1/4 mg or less might be all you need. On hematocrit, if the...

A little more info on sprifermin. It is also known as FGF18. From a US lab supplier it is $3240/mg. So costs are not unreasonable for 100 ug dose every 6 months per joint. I don't know if it is available from any of the Chinese suppliers, but if so, they certainly would be cheaper. It is...

Glad you're getting some relief. Here's something else that might help if you can find a way to source it: Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis Key Points Question Does intra-articular administration of...

It's irrelevant. Everybody is different. My genetics aren't going to be the same as anyone else's. But to satisfy your curiosity, it's 100 mg testosterone cypionate every 4 days.

Very happy I started TRT 5.5 years ago at the age of 47. I wish I had known how beneficial testosterone was and started much earlier. I had developed anxiety and depression and had no idea it was due to low T.

Not that we needed any more proof that the FDA only cares about maximizing profits for big pharma. They just don't care if they harm patients in the process. The statements they made to support their decision are ridiculous and easily proven to be false. There is loads of study data showing...

A more accurate statement would be that NIH wanted to curtail the use HRT in women and created a study to produce the desired outcome. The result was the WHI which was a dumpster fire of scientific malpractice. Entire books have been written about the WHI misconduct: Estrogen Matters by Avrum...

Rapamycin is not a senolytic compound. It is believed to have senomorphic effects, but this is poorly understood at this point. Most of the benefits of rapamycin are believed to be due to increased autophagy as result of MTOR inihibition. A senolytic compound kills senescent cells. A...

IA IGF-1 injections might be a viable treatment for joint issues. Here's an interesting paper where researchers genetically engineered chondrocytes to express IGF-1 then implanted them in the joint as defect repair. https://boneandjoint.org.uk/Article/10.1302/0301-620X.89B5.18343 This was...

All of the stem cell therapies are scams. While there's been great progress in taking adult cells and converting them to pluripotent stem cells, there's huge problems on the delivery side of things. Once injected in the body, there is no way to guide the differentiation of the stem cells. You...

Understood. Just thinking about how to characterize the difference between IA and subQ GH with some hard data. 5 weeks - that's pretty incredible. You should write a book about how to heal from injuries. It's a shame that our medical system discourages this sort of thing. I've been thinking...

It would be interesting to test serum GH levels 2 hours post injection with intra-articular vs. subQ. If similar, then I'm not sure you're really achieving meaningfully higher GH levels in the joint capsule. Theoretically an IM injection into the muscle nearest the joint capsule could produce...

Are you self injecting intra-articular? I know that there were physicians that would do this off-label in the past, but I believe the FDA has shut them all down.

There is a point where increased HCT reduces oxygen transfer capacity due to high blood viscosity. Blood viscosity can become so high with EPO that death is the result. Several pro cyclists died in the early days of EPO use until they understood more is not better. As to why pro athletes get...

I wondered what the impact of being categorized in one of these categories is, so I looked up the regulations. The net of it is as follows: Category 1: Not on the approved list, but the FDA won't take any enforcement actions if they are compounded. FDA is evaluating and may one day add to...