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I think more and more about trying to recreate a hormone pattern that is close to our physiology. I was just thinking about Progesterone not long ago, perhaps the most "physiologic" way of getting it in, being via injection. Pro, when taken orally will over convert to downstream metabolites...

there seems to be many reports on line of NAC causing insomnia, or distrubing sleep in some ways. If someone has some sort of sleep issues, I would avoid taking it at night.

I would get those tests done as well. You need to know where you are at with these hormones as well. If you have low progesterone and you bring that up, you may improve your anxiety.

Pregnenolone, Progesterone, DHEA, Thyroid, Cortisol. What is your level with that dose?

how much are you injecting daily? are you monitoring all the other hormones as well?

I'm wondering if you can still have withdrawal symptoms even if it is not a a benzodiazepine drug.

Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects H Viola 1, C Wasowski, M Levi de Stein, C Wolfman, R Silveira, F Dajas, J H Medina, A C Paladini Affiliations expand PMID: 7617761 DOI: 10.1055/s-2006-958058 Abstract The...

for sure running at supraphysiological Test level can do it, since test has an effect on the CNS. But other factors need to be taken into account here. Daily injection is a good way to see more precisely where your levels are with that particular dose.

Not sure this is just a coincidence, but for the past week I have been on 50mg apigenin, and sex drive, erections and libido have all increased.

I turned off all notification for that reason, calls texts included. I use it mainly to count my steps and keep track of my heart rate.

I see that using higher dosages seems to promote sedation, I use 50mg at bed time. how many days do you think you can use it before developing tolerance? I thought the first night worked great for me, second night still great but a bit less, 3rd night still benefited from it. Last two nights it...

That’s the brand I’m using. I started it as a sleep aid as well. It seems to be working. Hopefully it doesn’t effect hormones that much. I need to look a bit more into this.

Following up with this thread. Curios to know if anyone has seen any hormonal variation with the apigenin. The effect on the StAR was noted in an animal study, but wondering if can have an effect on E2 or DHT in humans

Hi @Nelson Vergel , have you ever completed this small pilot? Interested to know any outcome with the apigenin