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Do you know SHBG at any of these testing intervals ?

Prior to TRT +8 weeks on TRT Ref range Total Test 314 555 250-1100 Free Test 91.6 168 35-155 E2 35.98 36 <=29 TT/E 8.73 15 SHBG 14.4 12 10-50 PRL 8.25 12 2-18 So overall, I feel much better. Like life changing better. But I know there are...

Hey guys... as a big thank you for all the help, I put together this app to help others with their dosages... Testosterone Dose Calculator

On point 2… if one has low SHBG, they will tend to disproportionately aromatize to E2 + metabolize the T quicker … aka not get the same symptom relief as someone w normal SHBG… is that right? If that is correct, I think that explains my shitty results w enclo I have heard the same for people...

Thanks for the insight. You said you were T2D… what’s your SHBG ? I’d imagine lower end of the spectrum? Jatenzo and lower SHBG… how has that impacted for FT, e2, PRL, and DHT? Symptom wise… how’s libido. That has been the frustrating thing for me. W low SHBG… e2 and PRL seem to...

Agreed. Both times I have tried SERMs, they are great for a couple weeks or so… then dog shit. My e2 got to 77 on enclo and I literally couldn’t even think about sex. If I forced myself to, it felt like thinking about water polo or concrete. Two things I could care less about. Low SHBG...

Awesome! So with Jatenzo… do you “feel” the peaks and valleys… as they are pretty much happening in real time everyday? Is there a point in time, with consistent administration, where you are in a “steady state”. I know obviously it changes hourly… but does the brain and body know that… or...

Excellent. Thanks for the reply. So in theory, living w RA and it’s chronic elevated inflammation, it’s likely that my SHBG will be perpetually low. So if going on TRT+HCG, it would be imperative to start on the conservative end of dose with very frequent injections? @Systemlord arent you the...

Thanks for the insight. I am aware of that but from what I have read, while over training is a real thing… people tend to over estimate their output … I’m not a power lifter or athlete. I have started a caloric surplus and have decreased time in gym from 1.25 hrs to 45 mins. Prioritizing...

It’s been 6 weeks or so - had the periodontal deep clean + laser treatment on bacteria. - they put me on 2 antibiotics for 7 days after. - I started taking a good probiotic (and prebiotic) - eliminated gluten completely - crushing the gym - hill sprints - stopped taking enclomiphene -...

Very serious. The first time I drank alcohol as a teenager, I blacked out… and I’d have to imagine that 80% of the time until I quit drinking I blacked out. No accurate way to estimate, but a minimum of 500 times based on conservative math. Periodontal —> shitty self care as a teen, not...

Absolutely. Sounds like you made the right move for yourself! Wondering if you or anyone else subbed to this thread knows… I have researched this and haven’t found much… But what about the long term effects of frequent alcohol blackouts. Most things I see are related to how alcohol...

What was your age / T levels when you decided to start therapy?

I will start to research this as well Thanks for the info... Ya, I knew that I was not in the best shape but far from a pile of shit (like a lot of my peers). When the doctor told me I was pre-diabetic, I presumed she was trying to wake me up... My a1c was technically pre-diabetic, but one...

thanks for the suggestions. I am done w Gluten as of 48 hours ago... I never use seed oils, but this is a great point because it is next to impossible to know if a restaurant does, and roger that to the intermittent fasting window. I will check that book out asap I use myfitnesspal bc I am...

I will look these up and post later, but after that "reversal" they were all optimal

1) very hard to lose fat / put on muscle mild ED low libido brain fog / low motivations depression symptoms etc 2) very possible, and about the only thing that makes sense at this point 3) It is at the very low end of "normal"... I know that low SHBG is associated w IR / PD, so I thought...

Wow. Thank you sir. Turns out on Friday I am getting a deep clean at the periodontal dentist. Starting a. Antibiotic ahead of time and just ordered some probiotics and prebiotics and was just about to cut gluten and dairy again. Perhaps this latent periodonatal issue (bacteria in the gums)...

On other thing I was doing “when I felt good” and reversed PD was hill sprints. I will restart those as well. But Jesus…. Heavy lifting. Hill sprints. Logging everything I eat. Macros. All of this shit… just to barely feel good. And. I great way to find out why e2 dominates regardless of SERMs...

Ya. That was my original course of action. Reverse IR / PD … which for me entailed getting into shape. Now I’m in the best physical shape of my life with a very frustrating hormonal cascade.

Something else. At the beginning of this journey. Well actually before it started. I did a DUTCH test and two things that stood out at that time. I was not good at e2 methlyation … so I have thought that the “used” e2 that isn’t being removed could be getting put back in rotation and I don’t...

You’re saying that you would ditch the enclomiphene? As much as the high e2 sides of libido issues suck… it’s still better than it was before I started. If anything I have thought about ditching the enclomiphene and maybe trying an AI mono therapy. However, I felt like a billion dollars...

96 Yes... and it was much worse than it is now. I was taking 800mg of ibuprofin and smashing the gym. This likely was not the best thing I could do, but I was ignorant to my underlying conditions and had to fight against insulin resistance as hard as possible. I think by reversing the...

The hydroxychloriquine was added by my RA specialist to combat the arthritis... and since it mostly worked, prevented me from getting on a Biologique

Good point... I have just been following the Dr's protocol... This is a great idea, thank you

Thanks... I saw one of the bigger T clinics posted a YT video saying they were switching their TRT patients to ENCLO from HCG.... and that it was "better" for preserving testicles on TRT... But this was also at the time when HCG supply was low and its future in question... could have been a PR...

That is what I was thinking as well as I digested more and more of that the Urologist was saying. However the method of action is a bit different right... Currently the ENCLO is causing a spike in LH and FSH, which are in turn producing T and some of that is being converted in the testes...

Here is a breakdown of many labs over the past year. The actions taken after each one and the effects of those actions. Currently a bit confused as to what to do next and would love some insight. I have taken much interest and allocated a lot of time to learning this stuff and accordingly my...