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Not many docs advocate the blended approach, especially since it means you will potentially mix it yourself in sterile vial (although you could inject separately). That is good point about B12 and is why I try to avoid most supplements these days. It's just one more variable to deal with...

You may want to limit your variables in the beginning and focus just on TRT, adding in HCG down the road if you feel the need. HCG is a wildcard with guys reacting very differently

Inspired by @Cataceous, I have been tinkering with Enan/Prop blends for the past year. The idea behind the daily blend is to re-introduce daily T fluctuation. Inject first thing in morning to peak early in day and let levels come down overnight. For example, Cat’s personal data based on 4:3...

Ventro glute (VG) also good injection site for shallow IM. More you can rotate IM the better. Most people here avoid the quads

If you go the daily route, be aware that subq injections are the only practical option for the long term (unless you want to jab your muscle every day for the next 20 years). Lots of threads on here with advice for subq technique and which needles to use.

It will be interesting see how you fare with 1:1 versus 4:1. I lose water weight as soon as I increase the prop percentage.

It must be scanning this forum and not Reddit...

To add to other comments, you are injecting 2x the amount of T that healthy male produces naturally and your body is rebelling.

I've been following your posts on cream. I did try cream-only and just got too amped up on it similar to what some others have experienced. Not sure if that is the DHT increase. One protocol that has some promise is injectable base with cream for daily variation. I had some success but went...

Any updates on your selegiline use for dopamine boost?

You're only injecting twice per week so stick with shallow IM if you feel better on it. As you said, rotate sites and you will be fine. Subq shines when injecting small amounts daily for more steady protocol

No difference that I know of. My vials say the same thing. Sounds like you're doing well after the switch. I really like these 31 gauge x 5/16 syringes for daily subq: https://www.excelmale.com/forum/threads/daily-subqers-5-stars-for-bd-ultra-fine-insulin-syringe-31g-3-10cc-5-16.24643/...

And why would humans be deficient in B12 in the modern age? I can understand the cause of vitamin D deficiency because we are outside less, but less so with B12

In my case, apnea appeared to be driven by water weight. I had gained nearly 15lbs on my initial Cypionate protocol, most of it fluid. I started experiencing apnea for the first time in my life. The apnea soon disappeared after I reduced dose and switched esters to Propionate (and later...