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Is there any research to suggest that “high-normal” levels are best for overall health and sexual function? Everyone always talks about how men should aim for “high-normal” levels but I have always felt better just in the “mid-normal” range. I feel like advocating for “high normal” T levels...

What did you end up doing? Did you stay on the HCG mono?

Did you ever give Clomid another chance?

Do you have studies regarding 5-7mg per day number?

Unsure if my point got across in the previous post, but I think 1000iu /week could have even caused desensitization for you since you had a such a strong response to it.

So it seems like your reduced response was due to too much HCG. Also in your case, it seems like you had a very strong response to HCG such that 2000iu for a normal guy was like 1000iu for you. I could see how consistent usage of 2000iu in a normal guy may cause desensitization.

It doesn’t even seem like you used such large doses of HCG though, which is what is generally concerning. Though I wonder if you’re lack of response is due to too much HCG, or not enough.

It would be interesting to see a study Do I’ve seen studies that say 14-15ng/dl is the average FT, and I assume you have to. Do you rem Crazy that the HCG now adds zero to your T. Any idea why that might be? Have you been using the Pregnyl recently?

I would agree you with @Gman86 if the absorption of rate of injections wasn’t close to 100%, such as how we have the gels which absorb around 10% (Testim e.g. has 50mg of testosterone per gel). My understanding is that the rate of absorption for injections is close to 100%, right @Cataceous...

Thanks @Gman86 Always appreciate your input. Yeah my hope is that 350iu 3x a week produces a solid less E2 than 500 2x a week. I feel like it’s very hard to do 500 2x a week without an AI, but I never felt good taking the AI. Regarding the T dose, I’d rather start low and potentially titrate...

80mg (40mg 2x) weekly 1000iu HCG (500iu 2x weekly) and .25 AZ (.125 2x weekly). I think I’m going to drop the AI and separate the HCG into three shots weekly.

I am not. I switched off the HCG mono to the T+HCG after I banked sperm. My estrogen was high on the HCG mono even with AIs (on 3000iu a week and 1mg of AZ a week.) I think if I tinkered with the protocol more, I could have brought my E2 in range with a solid T level. The real kicker for...

How do you feel on that protocol?

@Cataceous The above appears like support for the law of mass action approach to understanding SHBG.

Is there any reason why Xyosted would provide better subjective results than regular Test E or C of the same dose? Can the lack of the preservative make that big of a difference? I’m highly considering switching from 80mg of Test C per week to 75mg Xyosted.

I’m dealing with exactly the same situation now. I took .125mg and my anxiety got really bad. I’m not crashed per se but I do feel bad. I think taking HCG should help but I’m always cautious of trying to compensate for fear of overcompensating.

Based on my readings, it seems like T mono protocols often do not require an AI, whereas HCG mono protocols often do require an AI. Where do T+HCG protocols stand relative to those two protocols? Is 1000iu a week of HCG generally enough to necessitate the use of an AI in conjunction with say...

I don’t even see why 100mg is ever necessary though. I bet the makers thought that it would be necessary for those with high SHBG.

Very interesting. My own experiences and labs I’ve seen across forums seem to support the hypothesis. When I did 75mg Xyosted for example, my FT was about 15/16–just above the male average. Also the Xyosted studies seem to support the hypothesis, as each dose produced a relatively large...

Many thanks. However, I never understood why injecting the same amount of testosterone would yield greater variations in TT than in FT. I’ve heard you mention this theory before but I still don’t quite understand it. My intuition would be that you inject a given level of T, and people would...

Is the posted E2 level actually a good one? If it was the non-sensitive test, your E2 might be closer to 75/80 (sensitive is usually 1.5x to 2.0x non sensitive) or potentially higher and people would say that’s high if they saw numbers like that. I feel like people are saying your E2 looks good...

I’ve seen you post here before that the 600-700 average TT level that is often quoted as the “healthy normal range” refers to the average peak TT level. Where did you read that? I believe the Xyosted 75mg pen produces a Cavg of around 650. Are you saying that someone taking Xyosted 75mg...

Apologies for my paranoia, but would taking a T vial on a trip reduce its potency assuming the temperature is always room temp? Would the vibrations from traveling reduce the potency the same way an HCG vials potency may be reduced?

I love this comment—particularly the “skewed perspective” about perspective you reference. Somehow, to many men, testosterone is the only hormone/blood marker that needs to be maxed out as much as possible. It’s interesting too because many will still acknowledge that there are side effects to...

This intracrine approach to E2 and serum testing is totally misleading and I don’t think Danny Bossa has any clue what he’s talking about. I read a Reddit post where he was arguing with a pro AI poster and Danny said “E2 is an intracrine hormone—look up what that means and tell me why AIs should...

That’s a great question and I’m not exactly sure what I meant by how it’s better. I think the fact that there is lower peak-troughs and that you’re less likely to feel “gassed” on the day before you’re next injection. I’ve heard people complain (and I ve had this experience as well using...

My basic point though was that TC injections subQ still have a better PK profile than Xyosted.

Pfizer lists the half life of TC as 8 days even for IM. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/085635s029lbl.pdf

Got it. Thank you for the clarification. It seems that 5 is too low for the TC half life SubQ.

What do you mean assign it a half life? I thought it was established that TC has a half life of 8 days. Also, the peak trough ratio for TC for just once weekly based on the above charts appears to be 11:7, which still beats the Xyosted ratio of 2:1. I’d imagine the ratio for TC injections would...

Lol same. Those charts are poorly labeled. I was confused what the takeaway was supposed to be other than SubQ is stronger than IM. The TC half life is still 8 days SubQ correct?