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  1. Vince

    Testosterone paradox of advanced prostate cancer

    Here is the take away from this article; "It turned out to be rather simple. When androgen levels are low, the androgen receptor is encouraged to “go solo” in the cell. In doing so, it activates the pathways that cause cancer cells to grow and spread. However, as androgens rise, the androgen...
  2. Vince

    Testosterone paradox of advanced prostate cancer

    High T lowers AR activity, ARSi increases. This is the whole idea behind STEP-Up. Quote from the research: «Acquired resistance is a significant limitation to the use of BAT. We show that acquired resistance to SPA can be driven by downregulation of AR in vitro. BAT induced downregulation of...
  3. Vince

    Testosterone paradox of advanced prostate cancer

    https://pmc.ncbi.nlm.nih.gov/articles/PMC6763228/
  4. Vince

    Testosterone paradox of advanced prostate cancer

    https://corporate.dukehealth.org/news/study-solves-testosterones-paradoxical-effects-prostate-cancer
  5. Vince

    On TRT over a year... feeling great but...

    Nelson started HCG and it helped him get his libido back.
  6. Vince

    On TRT over a year... feeling great but...

    Have you ever consider using HCG along with your testosterone? You could also try creatine.
  7. Vince

    Empower Enters a New Era of Advancement and Partnerships

    a snail? I guess you're saying they're too slow?
  8. Vince

    B12 Injection SubQ

    If your levels are not high I wouldn't be concerned
  9. Vince

    B12 Injection SubQ

    Several studies have shown an association between elevated levels of vitamin B12 in the blood and a higher risk of prostate cancer, with some research indicating that high B12 may stimulate prostate cancer cell growth.
  10. Vince

    Just had 1st CT Angiogram Scan done. Anyone experienced care to comment in simple layman terms?

    https://www.novartis.com/clinicaltrials/study/nct06267560
  11. Vince

    5 PROVEN Ways to Fix Low Libido Fast

    Most men who post on Male have issues. On average I don't believe most men on TRT don't have libido issues. This site is here to help men like you.
  12. Vince

    5 PROVEN Ways to Fix Low Libido Fast

    I wonder if estrogen estetrol (E4) would help? https://www.excelmale.com/threads/the-loss-of-estradiol-by-androgen-deprivation-in-prostate-cancer-patients-shows-the-importance-of-estrogens-in-males.31579/
  13. Vince

    5 PROVEN Ways to Fix Low Libido Fast

    Thank you, madman does have a lot of threads on the subject.
  14. Vince

    5 PROVEN Ways to Fix Low Libido Fast

    I really don't think that Nandrolone would help someone's libido. https://www.google.com/search?q=nandrolone+excelmale.com+site:www.excelmale.com&sxsrf=ACYBGNSqEqjpZKRLb1YARlOhk3DbNrGqJQ:1578064624559&sa=X&ved=2ahUKEwjJm4Tr3OfmAhWSWc0KHTp8BmEQrQIoBDAAegQIBxAN&biw=1920&bih=888
  15. Vince

    5 PROVEN Ways to Fix Low Libido Fast

    Also exercising improves libido.
  16. Vince

    5 PROVEN Ways to Fix Low Libido Fast

    I would have to think there's not very many men who are on TRT and still have a low libido.
  17. Vince

    Blood work questions

    I'm just saying what I need to feel good if my levels were that low or when my level were that low I felt terrible
  18. Vince

    Blood work questions

    Your testosterone is low, I'm surprise to see your high HCT.
  19. Vince

    Beating High Hematocrit – My Experience with Switching to Propionate

    I'm so happy for you. It sure is nice not having to donate blood. How long have you been injecting testosterone propionate?
  20. Vince

    Should I continue trt or not?

    Continue TRT until you get the results, if it's positive for cancer, you have to stop TRT. If it's not, of course you're good to go. https://pmc.ncbi.nlm.nih.gov/articles/PMC3668408/
  21. Vince

    Nandrolone and labs, changes?

    Here's mine https://www.excelmale.com/threads/my-first-labs-with-nandrolone.21828/
  22. Vince

    Treatment resistant acne

    For some people dairy especially cow's milk causes acne issues
  23. Vince

    Melatonin: functional significance for optimal cellular physiology - Prof. Russel Reiter (14/11/19)

    Both me and my wife take 120 mg every night. My joints feel great. No issues.
  24. Vince

    Melatonin: functional significance for optimal cellular physiology - Prof. Russel Reiter (14/11/19)

    I have lots of threads on melatonin. I'm currently supplementing with 120 mg nightly.
  25. Vince

    Injection site and scar tissue

    Use a insulin syringe. I use a 29 gauge 1/2-in syringe for Sub-Q and shallow. IM injections. I inject in my love handles, VG + shoulders. https://www.excelmale.com/forum/threads/best-testosterone-injection-site-no-aspiration-needed-avoids-all-nerves.7671/
  26. Vince

    Effect of Exercise for Depression: Systematic Review of Randomised Controlled Trials

    Throughout most of my life, I've always worked out and exercise. Maybe that's why I've never had any depression or anxiety issues.
  27. Vince

    Can an older man still build muscle while taking statins?

    https://vegan.com/blog/bill-clinton-discusses-his-plant-based-diet/
  28. Vince

    Can an older man still build muscle while taking statins?

    did Dr Esselstyn die from cancer at age 72?
  29. Vince

    Tadalafil: Northstar rxLLC/Alembic/Ajanta

    I use reliable RX for 10 years so far no issues
  30. Vince

    1st Defy Consult & Recommended Protocol

    That's the exact protocol I started a little over 10 years ago on my 60th birthday. I felt amazing and still do. I'm presently injecting 16 mg of Testosterone Cypionate daily and 500 IU of HCG every third day. I've never used an AI.
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