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This is exactly how I feel about the phenomenon and I almost fell into this trap when I crashed my estrogen. The more I read with these stories of "permanent damage" the more I was flipping out. I then realized I am a well educated medical professional with a knack to find the truth in...

I believe PFS is largely nocebo phenomenon but I think a small subset of men may not react well with the medication. The Harvard study was quite the slam dunk against PFS being an actual "thing" as the placebo groups reported more sexual side effects compared to the control group. Saying that...

Have you been evaluated for hypochondriasis?

//So since there is more seratonin floating around, to compensate for this your body downregulates the amount of seratonin receptors.// Same with dopamine, insulin etc....when there is too much, the receptors become desensitized and may not function at full capacity. This is what causes T2DM...

Being on testosterone has made my already thick hair thicker, my facial hair is also very thick and my body hair grows in thicker/faster as well.

I tried it today for the first time at US Cryotherapy, I’m hooked, I felt so much less inflamed

I have asked questions pertaining to your situation man, and I’ve also seen your story posted on multiple forums.

I didn’t make an assumption that “everyone needs to clean their diet ,” that is in reference to the book I mentioned on how to clean up genetic issues and improve methylation . As for your case , you’re not my patient , and I don’t have labs or diagnostic imaging on you in front of me to look...

So depending on person's genetic makeup, certain medications will disrupt methylation, once methylation is not optimal, you can get a myriad of side effects. Bad diet and poor lifestyle choices can also continue to "dirty" your genes and interfere with methylation. There is a genetic component...

Medications and anabolics can interfere with methylation, if methylation is out of whack, you can have all sorts of nasty symptoms. I'd suggest a book "Dirty Genes" by Ben Lynch. Arimidex may have caused some guys to have issues with methylation, and some may be more genetically predisposed to...

You just need to detox off the anabolics, they are harsh on your system if you're not running organ cleanses and other potent antioxidant throughout your cycle. You gut health can go to crap real quick, once that goes, you aren't properly absorbing nutrients. Anxiety is also a killer, and...

Yeah, anxiety will fuel the fire, I have crashed my E2, I have been there bro, I bounced back and recovered. Believing you may have some sort of crazy insensitivity or permanent condition is not going to do ANYTHING for your overall wellbeing, my friend.

These cases are different than what some of the dudes on here are going through, the guys on this board that make these claims have E2 levels in the therapeutic range yet believe they have an insensitivity toward estrogen. These guys on peak testosterone just have low E2 numbers that have not...

I don’t want anecdotes , I want data , present any data in humans to show that epigenetic changes occur, this is a well known and well studied drug . I have nothing to gain by disagreeing with your premise at all, I want to help people, that is why I am becoming a practitioner . You displayed...

//(his words were "there were some cases were somethign more omnious occured and things never got right again" its on peakT forum you can find it it's still there// Its possible, but it lacks data other than anecdotes. Maybe some are more genetically susceptible to being jacked up from Adex...

If you could show that arimidex causes any epigenetic changes to the receptor in humans and further changes to dopamine that is permanent in nature that would be vital. Not all women who take Arimidex have mood disorders, only a small subset do and only a small subset of women who are on...

https://mindhacks.com/2010/03/09/a-man-with-virtually-no-serotonin-or-dopamine/ This guy had no serotonin or dopamine and had no mood disorders or apathy, I feel like this phenomenon you guys are experiencing is largely psychosomatic. Clinically speaking, people with low dopamine present with...

have you gone the adrenal route? Perhaps getting a 24 hour saliva cortisol test ordered through Amazon.

Both TT and FT are important, you could argue FT is perhaps "more" important, but TT is not a useless measurement by any means.

I'd say look at what androgens do to the body physiologically (muscle growth, hair growth etc) and that should give you a good indication of receptor functionality.

Yes, I had great libido and great erections despite T levels in the 200-500 ng/dl range.

My last name is Maltese, my grandfather is from Malta!

Neurotransmitters being the sole component for causing depression and anxiety is based off poor studies and pharma wanting to push drugs that act on neurotransmitters. Do neurotransmitters play a key role in homeostasis? absolutely, but in my profession opinion (having years of working with...

Yes, you can potentially feel bad from crashing into the single digits. The first time I crashed into single digits I felt like crap for a month or two then felt better, I just recently crashed my E2 to 6 and had absolutely no symptoms of low E2. Your topic says "permanent damage" yet you...

//I am a Saw Palmetto sufferer// Funny how an herb that's been used for male virility for hundreds of years has never had any historical mention of side effects until it was found to reduce DHT levels in some studies although the data for this was poor, then all the sudden some dudes think its...

Exactly, I felt zero low E2 symptoms , unless there was a lab error my E2 is 6 on the SonoraQuest labs ultra sensitive assay. Waking up with wood, libido very high, strong erections , no mood problems, no brain fog , minimal joint pain, hair soft and skin not dry.

Oh yeah I’m def dropping the AI for a bit, I just think it’s interesting I have no low E2 symptoms this time around .

About a year ago I crashed my E2 to single digits and had anxiety, a little joint pain, and ED, night sweats . This time around I was just taking my standard .25 of Adex twice weekly and it was back in single digits but I was symptom free this time, had no idea it was even low . No joint pain...

My E2 is back into single digits again but this time as opposed to last time I have no low E2 symptoms, no ED, no joint pain, no overt anxiety, I was actually really surprised to see my E2 was low this time around, weird how the body works.

My main symptoms were fat gain around my mid-section and so-so gains in the gym and anxiety. I didn't have any problems with mood or libido or ED.

I've known quite a few guys who have used TRT for a long time that had to quit, all of them returned to baseline. "TRT for life" is a myth.