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Do you (or anyone on GSE) have Ferritin/Iron numbers? Do we know the method of action of GSE? i.e. Is it reducing gut iron absorption or reducing the formation of new RBCs?

This and Nelson's study are interesting. I'm looking to control HCT/Hb while having normal iron/ferritin. Right now I do phlebotomy and don't eat beef. That slows the growth of HCT/Hb but iron/ferritin are low. Looking at Nelson's study it says that they think Curcumin works by inhibiting iron...

This and Nelson's study are interesting. I'm looking to control HCT/Hb while having normal iron/ferritin. Right now I do phlebotomy and don't eat beef. That slows the growth of HCT/Hb but iron/ferritin are low. Looking at Nelson's study it says that they think Curcumin works by inhibiting iron...

Thanks all for this thread, especially @madman, I came here today to post about my experience.. I have been on 0.20ml (40 mg) EOD ~ 140mg/week for a long time and I feel OK. I tried increasing the dose by 20% to .24ml (48 mg) EOD ~ 168mg/week and I found: ~ Better pump/stronger in gym ~ Better...

HCT says normal but is at the very top of range, FYI. I would deal with that...

Thanks, couple more questions: 1. I know that to maintain sexual function, I have to take TC with ND. I think this is so that there is still DHT and E2 in the body. I read that you need between 2:1 and 1:1 TC:ND and I'm wondering if this is true and why? i.e. If someone needs 100mg/week of TC...

I had read that HL of T-Cypionate is ~ 6 days and HL of ND is ~ 7 days. Is that right? I took a larger initial dose and used the roid calc website to calculate dosages so that I could get to steady state sooner. I used this to get the ND level up and the T level down a bit more quickly than...

Thanks much, gentlemen! I'm experimenting for now. I want to live a long time so don't plan on any big and chronic doses. I'm already fit and strong and would like to add 5-10lbs (now 170lbs) more muscle if I can do it without causing harm. Previously, I was on 140mg T only per week. I'm...

Hi, looking for some "theory" here based on your experience. I'm trying to understand the effects of replacing some T in my protocol with Nandrolone vs. adding Nandrolone on top of the existing Testosterone dose. Here goes.. 1. Nandrolone drives polycythemia more than Testosterone. a. If I am...

Hey all, My GF (40 years old) has never done real labwork. I've got her eating healthy and working out. She said her doctor will order whatever she asks for. For a man, I know what labs are important. Some of those are the same for women, but they have the added complication of the female...

#134 - James O’Keefe, M.D.: Preventing cardiovascular disease and the risk of too much exercise - Peter Attia has a long audio interview Start listening at [1:24:15] Interesting here: SGLT2 inhibition for diabetes, cardio-protection, and general longevity. Attia says that he is taking an...

I had a friend who stopped taking aspirin due to stomach issues. Bleeding, I think. Only later did a doctor mention that taking it with food could alleviate that.. YMMV. Thanks for posting.

I have a baseline IGF-1 value and have been using MK677 for a few weeks. I'd like to run labs and check progress. How long does it take from increased GH levels to show up in the IGF-1 test? Thanks!

Causality vs. Correlation A year and half ago, I found this video where Neal Rouzier drives home the difference between Causality and Correlation as relates to E2 management. Basically the gist is that higher E2 is associated with bad health in the study population, but that study population...

FYI, I talked to a pharmacist, here in California and he said they were not allowed to dispense HCQ unless it was part of a trial. I then contacted my doc's office and now have some coming from a compounder. They are dispensing 10 doses only. So the idea is to only take it if I test positive...

With HCQ no longer on the FDA emergency use list, can doctors prescribe it off-label like everything else without risking their medical license?

This is a non-medical site, but passing along for the collective brain trust to review. A mysterious blood-clotting complication is killing coronavirus patients

Zinc seems to be one of the anti-viral keys. The NY Doc who has had very good results with treating Coronavirus uses HCQ + ZPack + 220 mg Zinc (!). This is for treatment, not prophylaxis and only for a few days, I am upping my Zinc and adding Quercetin and EGCG per the suggestions from the...

Any thoughts on how to dose EGCG/QCT + Zinc in humans if one needed to use them therapeutically?

Good article, but... would be good if we had references to people who have taken melatonin + vitamin C and could report on their progress. Better would be a controlled trial.

This is was for N=80 to followup on the earlier N=20 study in France. Interesting, they had cardiologists look at the QT time and excluded people whose heart QTc time made the risk-benefit not worth it. Maybe that will be part of the standard protocol...

Here's some posts from someone much smarter than me. He makes a good case that the virus had an accelerated evolution in lab ferrets (same ACE2 receptor as humans) which provided about 260 years of evolution from known relative Coronavirusis to Covid19. This method had already been used to...

Nice post. Very timely. The same guy has some other videos that look pretty good. i.e How to train all your back muscles at home..

I have been told that it's not the estrogen effects of estrone that are concerning, it's the metabolites that Estrone breaks down into: 2,4 and 16 hydroxyestrone. 2 is thought to be cancer protective and the others are pro-cancer. DIM is supposed to favorably alter the balance of those...

23andme. You can run it with a "new" email address and fake name to improve privacy. When I did it, there was an option to not share my genetic info, etc. The degree that they adhere to their confidentiality commitments is anyone's guess.

OK, so I did labs at trough: Free T3 2.5 (range 2.0-4.4) Reverse T3 9.9 (range 9.2-24.1) So, Reverse T3 is OK, which is probably not surprising because it's made from T4 which was low. Here's what I'm thinking: Free T3 trough is a little low at 2.5. At peak it was 6.1. Lowering the Cytomel...

Are you sure (re: fasting state slowing down metabolism)? I say that because Free T3 and Free T4 both look pretty good. The TSH is high which would seem to say the body is pushing the thyroid to make more hormone. Wouldn't we expect TSH, FT4, FT3 to be low if the metabolism was slowed? IANAD...

I feel OK but not great. Towards the end of the day I do feel cold and my body temp may be in the low 97's. It seems like I need more thyroid in the colder months. I am going to retest tomorrow before taking the meds and get a trough.

Hi, I have been taking 3/4 grain Naturethroid and 20 mcg Cytomel at about 3:30 am when I wake up to pee. At 8:15am, I did a blood draw. Results: TSH 0.922 (0.45 - 4.50) FT3 6.1 (range 2.0-4.4) FT4 0.67 (range 0.82-1.77) Am I taking too much cytomel or is this just a function of testing a...

Estrone is supposed to be more pro-cancer. E3 is Estriol and is supposed to be more cancer preventative. To take it further, I was told that it's the metabolites of Estrone which can be pro-cancer. I take DIM which is supposed to alter the mix of these metabolites. An aromatase inhibitor...

I just got some thyroid labs. I know normal ranges are not to be relied upon, but the range shows 9.2-24.1 so I'm not sure if single digits should really be the goal. By that logic, unless it's 9, you'd need to be below range to be in single digits. My latest labs were 12.5