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Big difference from the above photos: 20lbs lighter and did not have this issue. I am perplexed as to why this wasn't diagnosed from my ultrasound I linked above since ultrasounds are used to diagnose IRD. Maybe because they were focusing on the internal organs.

So, if that's the case, I can't think of what caused it. What do I do to correct it? I don't squat these days, only work legs once a week and do leg press when I do. Where I was lifting heavy was doing standing BB curls. I am attaching actual photos of myself. No amount of dieting or cardio...

No TRT while on metformin. My take: caution to euglycemic men in using metformin when not on TRT.

While all my T levels across-the-board tanked after starting metformin, my IGF-1 levels sharply increased from a baseline of 250 to almost 400 after taking tesamorelin, ipamorelin/CJC-1295. I am not on testosterone therapy at the moment and feel that anyone that is on metformin should be...

Somehow I've developed a distended abdomen/hard belly and umbilical hernia (inverted navel) similar to the attached photo. I cannot tell if it's visceral adipose tissue (VAT) or subcutaneous abdominal adipose tissue (SAT) - perhaps both. I cannot see my abs even when I flex so there's SAT. It's...

Please share the doc's contact info. PM me, if you wish not to post here.

Oral supplemental delivery of iron to raise ferritin levels has been a total failure for me. I have tried most every form of iron available in the states and abroad. Too much interference with gut bacteria, I suspect. The ONLY form, I believe, that may protect against the wrong gut bacteria...

Urgent: Does anyone know if Metformin discontinuation can cause rebound hyperglycemia? I am not diabetic but since July, had been taking Metformin for anti-aging, cardiovascular and many of its other benefits, however, because it was tanking my testosterone levels to all-time lows (see my post...

1 month update - officially in the tank whether it's from Metformin or not. Latest labs as of 12/6 are confirmatory for secondary hypogonadism: TT: 347 FT: 48.2 BIO: 99.2 SHBG: 30 E2: 11 Again, main concerns with proceeding with TRT: Given my history of hypercoagulopathy (past clots in both...

A few doctors have touted the little-known thyroid hormone T2 to be used to help burn brown fat. Since there is only a tiny amount (8mg) in my NDT, I was thinking of adding it for the purported benefits...

https://www.peptidesciences.com/kisspeptin-10?queryID=330b154d45e02649aed60369fa245d8b&objectID=154&indexName=m1_default_products

Just came across this YT video:

I have a friend who's been on clomid and adex for several years and his T land E2 labs look great and he feels great. I just don't like the possible estrogenic aspect, but that hasn't seemed to be a problem for him, so, was thinking of giving enclomiphene a shot. If I did TE, I would be...

Due to my existing hypertension and past hypercoagulopathy, perhaps I would be best advised to try a SERM (i.e. enclomiphene) before jumping to frank TRT. Thoughts?

I am not T2D but prone to it, so unlike the test subjects, am taking Metformin electively as a geroprotective and prophylactic agent. The question is whether staying on it indefinitely will eventually necessitate TRT. I was already low normal and considering TRT [June, 2022 (pre-Metformin): TT...

What would be a "safe" low dose starting point for someone who has hypertension and past clotting issues, both of which are being managed by meds, exercise, diet? 20mg?

I posted my T labs above. I think it's pretty obvious Metformin had a sustained down-regulating effect on my levels. I will test again soon to see if it leveled off. How many others have seen their T levels plummet when on Metformin (on or off TRT)?

It definitely tanked my levels (see below) and I would advise the anyone who's not T2D be aware of this and perhaps not take it unless you're hormonally optimized (on TRT). June, 2022 (pre-Metformin): TT: 553; FT: 76.9 August, 2022 (1 month Metformin): TT: 415; FT: 70.2 November, 2022 (4 months...

My joint pains have worsened to which I attribute both low T and E2 symptoms. I think it's obvious I should d/c the Metformin until I get my hormones optimized.

My glucometer app does:

5-7 180lbs - but even when I weighed 20lbs less, my BP did not lessen. Have tested my DNA extensively for hereditary clotting issues and nothing came up except MTHFR. I feel I need be on TRT at this point and think I should d/c the Metformin for now until my T levels are optimized. Maybe start...

low 100s if I don't fast for at least 12h, in the mid to high 90s if I do. If I eat even complex carbs for dinner, FBG will go into the 110-115. A1C 4.9-5.2. Metformin doesn't seem to influence those numbers either way. I take 1g with last meal and 500mg before sleep.

Observations being on ER-Metformin for last 4.5 mos. (started July 1, 2022) 15lbs weight loss - no change in diet or training No GI problems up to 2g/day No change in fasting glucose levels or a1c (not diabetic to begin with) *Substantial decrease in total and free T (not on TRT): June...

Yes.

Observation - Progressive increase in blood pressure/pulse averages: last 12 mos: 127/79/63 last 6 mos: 126/80/64 last 3 mos: 128/82/68 last mo: 131/84/67 causes: increasing NDT>increased serum T3 = elevated BP/pulse?

Have been doing it before for the last several labs this year to measure the effect of the dose.

When you say to keep your FT3 levels high, how high? I, too, have lately been doing my labs the same morning I take my NDT dose to see how the medication is working. And it is working as I can tell from the labs I posted on above. I guess I shouldn't be concerned with being a bit over range on...

That one relates to TSH over-suppression. Fortunately, not my problem. In fact, my issue has been high normal TSH and trying to suppress it more by gradually increasing the dose of NDT which it appears I have done. That latest level of 1.23 is right around where I need to be.

Didn't get rT3 tested this time, but I usually hover around 19 (but that was at a lower dose of NDT). Will test again soon. What I really am curious to know is whether too much T3 can accelerate cartilage degeneration which would give rise to OA and injuries. Maybe it's completely unrelated...

Never have had an indication of Hashi's from dozens of past labs and ultrasounds and as I indicated, I am on NDT, not Synthroid.

Latest labs (last dose of 2.50 grains (162.50mg) NDT taken only about 6h prior to draw): TSH:1.23 ref range: 0.450-4.500uIU/mL FT3: 5.00 ref range: 2.0-4.4pg/mL FT4: 1.60 ref range: 0.82-1.77ng/dL Anyone notice that too much T3 from desiccated thyroid causes a flareup in joint pain? Is a 5.0...