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I have low SHBG - it was 12 in my last bloodwork - and that is pretty much where it's been for the previous ten years, but I have no trace of metabolic syndrome, and I am not diabetic or pre-diabetic. With low SHBG, I do not "feel" my TRT at all. On TRT and with good blood numbers for free T...

Also, with low SHBG guys, the problem is not how to get steady levels (Inject daily or use cream) the problem is we often feel nothing at all from TRT. Being on TRT still feels like Low T for most of us.

I tried it for 8 weeks a few years back. It did nothing raise my SHBG.

Lots of these things do raise SHBG but by a very tiny amount at most, so it's not enough to help low SHBG guys like us.

I am glad it is coming back!

Has your TRT protocol changed at all? Do you have blood work? I have never gotten a libido boost from TRT so I feel your pain.

I have had the opportunity to try them 3 times over the last 12 months or so and all I got was some weird muscle shakes that lasted for hours and the sensation that colors were more intense or more vivid. Dosages were 2 grams, 3 grams, and then 4 grams for my last dose I have some anxiety and...

Things like coffee raise the level by a very tiny percent as well. Not enough to help you if you are a low SHBG guy.

I have used this to tan before going to Hawaii as I am very light-skinned and it allows me to get a seriously dark tan so I don't have to cover myself in SPF 100 sunscreen when I go to the beach. Never got much in the way of libido out of it, but if you want a dark tan that lasts and lasts, I...

57 years old. TRT for 10 years, no libido at all, tried all known protocols except injectable pellets. Quad Mix works but with no libido, I don't even care.

Thank you. I will give that a go.

It is interesting how this works wonders for some and does nothing for others. I have wasted way too much money on this to try to fix some shoulder issues and I may have well been injecting saline in terms of effectiveness.

If you are just doing the 6 weeks, then one could argue it's not long-term use so I would think you would be fine.

There is no way to raise very low SHBG, either. I know all too well.

A lot of folks on TRT, including myself never find good libido even when working with the best doctors.

Yes, both before bed. I have sleep issues where I go to sleep fine and sleep good, but wake up at like 3:00 AM, wide awake and unable to get back to sleep until about the time I need to get up for work at 6:00. These two supplements allow me or help me to sleep until the alarm goes off most nights.

I take oral DHEA 10mg and apply pregnenolone cream 10mg before bed to help me sleep. That's the only benefit I have ever noticed from either or both of them - they help me sleep better and not awaken at 3-4 am and not be able to get back to sleep.

That you for the update. I too have never felt any relief from BPC 157, and I was trying it for some minor muscle injuries, not arthritis or something similar where one would not really expect it to help.

A lot of us on TRT never regain a good libido. Many if not most people assume we are doing something wrong, need a new protocol, we don't get enough sleep, exercise, or we eat bad, etc...But for many of us, we have tried literally everything after 10+ years on TRT and it never happens. That...

That sure looks like a "watered down" Test. From the pharmacy I mean, not your dosing which has not changed. A set of bad labs would not account for your feeling like TRT is no longer working.

Even on TRT, I do not recover well from exercise and I have a very low libido. On Anavar, my ability to recover from exercise was so bad that I was always sore and could not recover at all and lost strength, and my already low libido flatlined. About 3 weeks after stopping I was back to my...

I ran Anavar prescribed from Defy at 25mg a day and it made my TRT far worse, not better. Dropped my SHBG to 7 and I had to quit using it after 6 weeks. Plus it is very expensive. Your results may vary.

The big question is how do you feel on your protocol? If you feel good, then no worries about testing or not testing. If you feel bad and adjustments are needed, then knowing your SHBG is super helpful. If your endo doesn't think it matters, I would think about switching docs.

I can't believe he didn't prescribe FSH right away? Or if not right away, right after seeing how increasing HCG didn't help. Guys that remained on TRT and used FSH have become fathers.

They work great - for the clinics that sell them. $$$ It is annoying how they vastly overpromise products like this.

I tried it for 6 months and just stopped as it made everything worse for me. Lower libido, lower recovery in the gym, etc. No change in my PSA, though.

I have tried micro dosing magic mushrooms but felt/noticed nothing. I understand that by definition a microdose is below the threshold of perception, but over time I never noticed any reduction in anxiety or increased productivity, or increased focus. But, nothing I take seems to work for me...

On the 40mg of 1-Test cyp, is that once a week?

Same with me.

Great list for sure! In my case when I tried TB-500 I was trying to fix soft tissue issues, like for example a shoulder that would not fully recover. I stopped the exercise that irritated it and used other exercises instead and had hoped the TB-500 would help it heal. I then went to a physical...

Great ideas! Thank you for posting