HCG change from USP to Pregnyl sudden side effects

evolution69 · Friday at 10:49 AM

Hi All, My pharmacy was out of my regular HCG USP and switched me to Pregnyl. They said is would be the same but I have been having sudden insomnia and just a general increase in nervous energy that is hard to explain. I have tried reducing my dosage to half which seems to help somewhat. Any idea why this would happen? Is Pregnyl stronger somehow?

BTW my estradiol always seems to ride at the upper ranges and often a little out of range since I started HCG USP a couple of years ago, but I haven't got any blood draw since starting Pregnyl.

FunkOdyssey · Friday at 10:58 AM

evolution69 said:
Any idea why this would happen? Is Pregnyl stronger somehow?

Pregnyl is renowned for being the strongest available hCG, so yes, it being stronger than USP is my guess to explain your reaction.

evolution69 · Friday at 11:00 AM

FunkOdyssey said:
Pregnyl is renowned for being the strongest available hCG, so yes, it being stronger than USP is my guess to explain your reaction.

Thank you. I had no idea! I guess the old stuff was a lot weaker. I will try lowering the dose some more.

t_spacemonkey · Friday at 11:09 AM

could be due to high e2. i had a similar issue with too much hcg, if you have an AI on hand it fixes issues within 24h (did for me), you got the answer

evolution69 · Friday at 11:16 AM

t_spacemonkey said:
could be due to high e2. i had a similar issue with too much hcg, if you have an AI on hand it fixes issues within 24h (did for me), you got the answer

I don't have an AI but next time I see my doc I will ask for a script for cases like this. I am injecting twice a week so it should calm down fairly quickly if I skip the next one. HCG half life appears to be around 2.5 days.

Vince · Friday at 1:41 PM

FunkOdyssey said:
Pregnyl is renowned for being the strongest available hCG, so yes, it being stronger than USP is my guess to explain your reaction.

I would just stop using it for a few weeks, and see how you feel.

evolution69 · Friday at 2:54 PM

Vince said:
I would just stop using it for a few weeks, and see how you feel.

Yes probably a good plan.

Ryan474 · Sunday at 10:09 AM

I am pretty sure I notice a significant variation in the 'potency' of effect on pregnyl from vial to vial. If I understand correctly, it's purified from pregnant women's urine? I have no idea what standards are in place for their manufacturing practices, but it would seem plausible that there is actually a difference in potency from one batch to the next. I also can't help but wonder if there are other 'impurities' or chemical differences in it. I've recently come across this idea that pharma or generic hgh can have varying amount of dimer levels, resulting in potentially different side effect profiles. I wonder if something similar could be happening with pregnyl. I don't have the expertise to know if any of this is possible/plausible, and ultimately the variation I feel is tolerable so it doesn't matter a whole lot.

I have been on Pregnyl since September 2022, so have gone through over 15 vials in that 27 month period. My hypothesis (only from subjective feeling on it for >2 years) is it's often overly-potent after first mixing, giving more than 10,000 iu per vial. Then fades and depending on how the vial is used and stored, by the 6 or 7 week mark is quite weak and the effects are subjectively quite different than when started. It seems not just "weaker effects". More like "still disrupting sleep about the same, but not boosting mood the same at all".

It seems pregnyl felt more powerful than the empower hcg I was on prior, though that may have been related to it getting degraded in shipping from empower or poor manufacturing practices or something. By ordering Pregnyl from optum, with next day delivery, I think it's much less likely to degrade from heat.

MarkP · 2024-12-11T13:00:17-0600

Just curious what the cost is for a standard 10,000 iu of HCG from optum?

mooseman109 · 2024-12-11T19:36:38-0600

I have noticed that pregnyl is stronger than the compounded product. I reduced my dose a bit from the other stuff

HCG change from USP to Pregnyl sudden side effects

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