Should I worry about high E2?

Nixter · Sep 27, 2024

49yr old male. On trt for 7 years and still chasing the perfect protocol. I'm close though. 75mg/wk divided Mon/wed/fri. 1000ui HCG divided the same. Recent blood work had my total T just above mid reference, my free T near the top of reference, and my Estradiol, double the upper reference!

I feel good here though. Should I be concerned about the high E2? I'd rather not take arimidex if possible. I'm lowering my HCG to 500UI a week but I'm concerned about libido and Im doubtful it will impact E2 levels THAT much anyways.

Systemlord · Sep 27, 2024

Nixter said:
I feel good here though. Should I be concerned about the high E2?

Estrogen is 50 times higher in the tissue concentrations and doesn’t exert much effect outside of the tissue other than to regulate other hormones. The serum estrogen is what’s left over and is a small piece of a much larger picture.

Nixter · Sep 27, 2024

Systemlord said:
Estrogen is 50 times higher in the tissue concentrations and doesn’t exert much effect outside of the tissue other than to regulate other hormones. The serum estrogen is what’s left over and is a small piece of a much larger picture

I'm not exactly sure what you're saying. I shouldn't worry about it?

Systemlord · Sep 27, 2024

Nixter said:
I shouldn't worry about it?

I would be worried about it if you had negative symptoms, which you don’t. Men who treat a high estrogen values in the absence of symptoms usually end up with negative symptoms.

Medicines used to block estrogen block it inside the tissue, this is where the symptoms or lack there of come from. If you were to go on an aromatase inhibitor, you could have normal estrogen and still have negative symptoms.

We have a few members, far from common, who have had symptoms of low estrogen levels for years after going on an aromatase inhibitor even though their estrogen level have recovered.

My advice, don’t screw with your hormonal pathways by blocking the conversion of other hormones because this can have unknown consequences down the road.

Nixter · Sep 27, 2024

Systemlord said:
I would be worried about it if you had negative symptoms, which you don’t. Men who treat a high estrogen values in the absence of symptoms usually end up with negative symptoms.

Medicines used to block estrogen block it inside the tissue, this is where the symptoms or lack there of come from. If you were to go on an aromatase inhibitor, you could have normal estrogen and still have negative symptoms.

We have a few members, far from common, who have had symptoms of low estrogen levels for years after going on an aromatase inhibitor even though their estrogen level have recovered.

My advice, don’t screw with your hormonal pathways by blocking the conversion of other hormones because this can have unknown consequences down the road.

Thank you. Im pretty sensitive to adex. My joints and vision do not approve.

Should I worry about high E2?

Nixter

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Systemlord

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Nixter

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Systemlord

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Nixter

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