What makes scrotum application convert more into DHT?

[Dwayne337]

For transdermal testosterone, what exactly is the reason scrotum application results in much higher DHT conversion than other areas?

Is it JUST because of the higher absorption rate of the scrotum skin?

Does testosterone absorbing/interacting with the testicles have anything to do with it?

 

[Systemlord]

The skin on the scrotum is 6x thinner than anywhere else.

 

[madman]

For transdermal testosterone, what exactly is the reason scrotum application results in much higher DHT conversion than other areas?

Is it JUST because of the higher absorption rate of the scrotum skin?

Does testosterone absorbing/interacting with the testicles have anything to do with it?

In general, transdermal will cause a higher conversion of T-->DHT compared to injectable due to a high degree of 5α-reductase activity in the skin.

Scrotal skin is denser in the 5α-reductase enzyme resulting in increased conversion of T-->DHT.

Testosterone cream applied to the scrotum has 5-8x greater absorption compared to gel/cream applied to the body (shoulders/arms/chest/inner thighs).

The skin metabolizes testosterone to DHT by 5α-reductase, and the greatest 5α-reductase activity is found in genital skin