Obstructive Sleep Apnea: Diagnosis and Health Consequences

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Nelson Vergel

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[FONT=&quot]Obstructive Sleep Apnea (OSA) can lead to oxidative stress, inflammatory processes, endothelial damage, sympathetic activation and metabolic dysregulation that predispose to atherosclerosis, and so OSA is a common cause of systemic hypertension.

During OSA, episodes of hypoxemia can drop the oxyhemoglobin saturation from 95% to 80%, depending on the length of the period of apnea [[/FONT]
8[FONT=&quot]]. OSA is an independent risk factor for cardiovascular and cerebrovascular diseases. Due to hypoxia, the oxidative stress leads to overproduction of reactive oxygen species which can cause endothelial dysfunction, resulting in atherosclerosis [[/FONT]9[FONT=&quot]]. The inflammatory marker C-reactive protein (CRP), tumor necrosis factor α (TNFα), and interleukin-6 (IL-6) were increased in patients with obstructive sleep apnea, and they were significantly higher in cases of severe obstructive sleep apnea, where the AHI was 15 or gr

 
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