Naringin and tadalafil

[Cameron58]

I understand that consuming grapefruit and grapefruit juice can interfere with tadalafil. But what is the specific component of grapefruit that does this? Would naringin (grapefruit seed extract) have the same effect on tadalafil as eating a whole grapefruit would? Yes, I did search the archives, and did not find an answer. Thanks.

 

[Vince]

Furanocoumarins in grapefruit that disrupt the normal function of cytochrome P450 (CYPs).

Yes, it's also in grapefruit seed extract.

 

[Jed Dorsey]

Maybe it effects some and some it don’t. I take Tadalafil regularly and eat lots of grape fruit boner city here LOL

 

[Cameron58]

Maybe it effects some and some it don’t. I take Tadalafil regularly and eat lots of grape fruit boner city here LOL

I think that's the point. An enzyme in grapefruit (and grapefruit seed extract) causes tadalfil to break down slower in the body. So if you take it every day you end up with a higher does in your body than you realize. A higher does can certainly help you visit "boner city", but can also result in more side effects.