Ideal TT for longevity?

[Steve78]

I read an Australian study that a TT between 300-500 men lived the longest. Is there any other studies or thoughts on the ideal TT level for optimal health and longevity? I did read an E2 between 20-30 was ideal for longevity.
My goal at age 43, just had a baby (number 6) is to live as long as possible but also feel good as well.

 

[ajax31]

Unfortunately I didn't save it, but I've seen a study that indicates a body weight above 200lbs in men is associated with a shorter lifespan. The bigger you are and the more you weigh - even taking into account muscle mass and body composition - that 200 remains the magic number. Maybe it has to do with the heart having to work harder to pump the blood and perfuse all the tissues and organs in a larger man.

Anecdotally, most of the very elderly men I've seen tend to be of the wiry type (thin but strong).

 

[Steve78]

Unfortunately I didn't save it, but I've seen a study that indicates a body weight above 200lbs in men is associated with a lower lifespan. The bigger you are and the more you weigh - even taking into account muscle mass and body composition - that 200 remains the magic number. Maybe it has to do with the heart having to work harder to pump the blood and perfuse all the tissues and organs in a larger man.

Anecdotally, most of the very elderly men I've seen tend to be of the wiry type (thin but strong).

Yes most 90 year olds seem petite to me.

I’m 6’4 240, so I’m screwed, lol.

I’m going to start leaning out as I do barely any cardio. I’m trying more plant based and more cardio. I already do resistance training 5x a week and look fit, just have to lose the dad tummy

 

[ajax31]

You can do it.

I'm 6' 4" and 200lbs.

 

[Steve78]

Ok.

Back to my original post, my TT was 700 on 100 mg test weekly. A friend who is a trt doc in California told me to up it to 140mg weekly and I feel amazing! I’ll check labs soon but I’m assuming I’m around 900-1000 TT and I’m concerned it may affect how long I live.

 

[Vince]

Unfortunately I didn't save it, but I've seen a study that indicates a body weight above 200lbs in men is associated with a lower lifespan. The bigger you are and the more you weigh - even taking into account muscle mass and body composition - that 200 remains the magic number. Maybe it has to do with the heart having to work harder to pump the blood and perfuse all the tissues and organs in a larger man.

Anecdotally, most of the very elderly men I've seen tend to be of the wiry type (thin but strong).

Obesity cuts life span dramatically, studies find - The Globe and Mail

www-theglobeandmail-com.cdn.ampproject.org

 

[Graham]

Ok.

Back to my original post, my TT was 700 on 100 mg test weekly. A friend who is a trt doc in California told me to up it to 140mg weekly and I feel amazing! I’ll check labs soon but I’m assuming I’m around 900-1000 TT and I’m concerned it may affect how long I live.

It seems most of this comes down to the cardiovascular system. Between the bodyweight and dosage- higher dosage leads to more sides such as polycythemia. It also leaves you feeling more stimulated which I guess can effect the heart over time.

 

[Steve78]

I’m guessing it doesn’t matter much if my TT is 1100 as long as BP, and bloodwork are within normal limits

 

[Graham]

I’m guessing it doesn’t matter much if my TT is 1100 as long as BP, and bloodwork are within normal limits

Don’t forget the CNS factor, for me to obtain levels near 1,000 ng I have to take 200 mg per week. I feel better and worse there at the same time. It’s a trade off, I can’t deny the constant stimulation part. It’s something I didn’t realize until recently.

 

[Systemlord]

I read an Australian study that a TT between 300-500 men lived the longest.

I seriously doubt it. All other data shows something different.

Testosterone Threshold for Increased Cardiovascular Risk in Middle-Aged and Elderly Men: A Locally Weighted Regression Analysis - PubMed

These data showed that a testosterone threshold of 440 ng/dL was associated with increased Framingham 10-year CVD risk in middle-aged and elderly men. Poor sexual performance, decreased morning erection, and loss of libido had an impact on the testosterone threshold for CVD risk. The threshold...

pubmed.ncbi.nlm.nih.gov

 

[Steve78]

Don’t forget the CNS factor, for me to obtain levels near 1,000 ng I have to take 200 mg per week. I feel better and worse there at the same time. It’s a trade off, I can’t deny the constant stimulation part. It’s something I didn’t realize until recently.

What do you mean constant stimulation? When my TT goes up I feel less anxiety and more calm

 

[Steve78]

I seriously doubt it. All other data shows something different.

Testosterone Threshold for Increased Cardiovascular Risk in Middle-Aged and Elderly Men: A Locally Weighted Regression Analysis - PubMed

These data showed that a testosterone threshold of 440 ng/dL was associated with increased Framingham 10-year CVD risk in middle-aged and elderly men. Poor sexual performance, decreased morning erection, and loss of libido had an impact on the testosterone threshold for CVD risk. The threshold...

pubmed.ncbi.nlm.nih.gov

So they are saying a TT under 440 was associated with higher cardiovascular risk?

 

[Systemlord]

So they are saying a TT under 440 was associated with higher cardiovascular risk?

That's what it says. There are many studies showing the same thing.

 

[Steve78]

That's what it says. There are many studies showing the same thing.

Ok, that’s good news. I’ll shoot for 800-1000 and try to keep everything else as healthy as possible

 

[Rabbit91476]

As I gradually increased my dose from 100 ton200 mg. I recover better from the occasional over drinking. Do better in less sleep. But if I wake up to pee after 330 I find it hard to fall back asleep. It’s rare for me to sleep 7 hours before my body wakes me up. Which I guess makes me feel “ better and worse at the same time”.

 

[Steve78]

As I gradually increased my dose from 100 ton200 mg. I recover better from the occasional over drinking. Do better in less sleep. But if I wake up to pee after 330 I find it hard to fall back asleep. It’s rare for me to sleep 7 hours before my body wakes me up. Which I guess makes me feel “ better and worse at the same time”.

I see

For me, my sweet spot was going from 100 to 140. I do 40mg SQ EOD

 

[TorontoTRT]

The only true answer is genetics.

 

[JimGainz]

I wouldn’t put any faith in that study. Look at the range: 300 ng/dL total testosterone is what you see in 90 year old men. (Which supports the theory in some degree but you have to probe deeper and ask - Do I want to be that 90 year old skinny weak man?). It reminds me of a study I read where in a certain part of the world people who eat this plant-based diet lived to over 100 years old. Wrong metric in my book. Have you ever seen a 100 year old person? My grandmother lived to 102 and I wouldn’t want that for myself. So, the studies do not factor quality of life.

Besides, the only real metric that we know is that low testosterone has a link to mortality. So I wouldn’t waste any time trying to figure out if a particular range is going to make you live less so long as it is in a normal “healthy” range.

 

[MIP1950]

I wouldn’t put any faith in that study. Look at the range: 300 ng/dL total testosterone is what you see in 90 year old men. (Which supports the theory in some degree but you have to probe deeper and ask - Do I want to be that 90 year old skinny weak man?). It reminds me of a study I read where in a certain part of the world people who eat this plant-based diet lived to over 100 years old. Wrong metric in my book. Have you ever seen a 100 year old person? My grandmother lived to 102 and I wouldn’t want that for myself. So, the studies do not factor quality of life.

Besides, the only real metric that we know is that low testosterone has a link to mortality. So I wouldn’t waste any time trying to figure out if a particular range is going to make you live less so long as it is in a normal “healthy” range.

In the book, 'The Blue Zones' the focus was on areas of the world where men and women have extraordinary longevity. One place was the Greek island of Ikarias. They eat a mostly plant based diet, drink homemade wine, homegrown honey, dairy products from goat's milk and whole grain bread. Men in their 80's, 90's, up to 100 claimed that they were still sexually active, which could mean weekly to once or twice a month.

In the 1900's Elias Metchikoff, Ph.D, a Russian microbiologist, explored cultures that consumed fermented milk products, daily, and believed that was a key to their longevity and, to good health, in general. However, he also acknowledged that where they lived and how they lived were likely factors, also, to longevity.

For another take on this, there was an African-American women in DC, 100, who said her good health came from drinking a glass of Guinness every day. There are many interesting. even tantalizing areas to explore in regards to finding the keys to robust health and longevity, including the role of hormones, but a 'formula' has yet to emerge. And genetics/epigenetics are significant critical factors. For me, at 71, I'm still physically strong, not from exercise. Seems to be a genetic endowment. My grandfather and father, both small and wiry, had good physical strength. I'm less wiry than I was 30 years ago, but I still do push ups and use hand grips(100 repetitions). I walk a lot. Hip and ankle issues ended my jogging a few decades ago. But, severe mental illness and poor sleep have been eroding my health for 17 years.

 

[Sergel]

Who paid for that study. Pharmas don't like testosterone. There is no money in testosterone and they also prefer putting men on antidepressors and other money drugs.

Do you have a link to the study?