This is been said before and this will be a very straight-forward post, but the low dead-space fixed needle/syringes are well worth it. I recently switched to daily shots (which by the way has been extremely beneficial and will get its own post after my next set of labs). Anyway, upon switching to daily, I recognized that a substantial amount of T would remain in the needles that I'd been using for almost a year since starting therapy. I was using the luer-lock (the detachable type) easy touch 27 guage, 1/2 inch needle/syringe. I wanted to switch because of the lost medication from every injection - I do 18 mg a day and I'd estimate there would be 5/6 mg lost with every injection, perhaps more sometimes, so basically 1/3 gone. Anyway, I called Defy and asked for the low dead space fixed insulin needles/syringes. they don't sell them so I ordered from OTC wholesale after after reading threads here from Madman, Nelson, etc. Just started using these and they are so worth it. I use the .5 ml syringe with 27 gauge needle, 1/2". Not only do they fill faster, the needles I swear are much sharper and I feel almost absolutely nothing in my injection areas (rotate between delts, quads, and hip/glute-medius). Also, they just fit in your hand much better, and it is much easier to read and measure with the smaller .5 ml syringe. And I can verify there is basically no lost medication - with my old needles, after injection, I could easily force out a lot of oil that I could not get into my muscle no matter how long I pushed on the plunger. After a year of what I now see as 'shot-anxiety' I am finally actually almost enjoying the ritual. It's actually satisfying if I am trying to find the right word for it. ANd they are cheap: only $17 for 100. Only thing I may tinker with on my next batch of needles is going down from a .5 ml syringe to a .3 ml. Again I'm only doing 18 mg a day, which equates to .9 ml (or 9 'units'). Seems like the smaller syringe is more appropriate with the smaller dosing. So this is for those starting out or others still looking to dial in their shot ritual.... well worth trying in my opinion. Here is the link for the product I purchased... Easy Touch Insulin Syringes 27 Gauge  |  0.5 CC Insulin Syringes