Daily Injection Experiment

[DragonRider]

I started doing daily dosing of Test Cyp at the beginning of November. About 4 1/2 months from my most recent blood test. The goal was to find an injection schedule that would naturally lower my estradiol and hematocrit levels.
My dosing schedule has been 16 mg on Sun, Tue, Thurs, and Sat and 12 mg on Mon, Wed, and Fri for a total of 100 mg per week.

These are my latest results.

TESTOSTERONE, TOTAL, LC/MS/MS (ng/dL) 644 (range 250-1100)

FREE TESTOSTERONE (pg/mL) 212.6 (range 35.0-155.0)

ESTRADIOL Ultrasensitive LC/MS (pg/mL) 65 (range < OR = 29)

HEMATOCRIT 48.5 (Reference Range: 38.5-50.0 %)


I'm happy with the total testosterone, but not so much with the estradiol and the hematocrit. These numbers seem to be consistent with the numbers I get from once a week and twice a week dosing.

I can't use AI's to lower estrogen because I have stage 2 kidney disease and AI's cause me to bleed and pass quarter size blood clots from my kidneys, and of course DIM doesn't do anything for me. The estradiol makes my ED much worse.

Any ideas would be greatly appreciated.

 

[madman]

I started doing daily dosing of Test Cyp at the beginning of November. About 4 1/2 months from my most recent blood test. The goal was to find an injection schedule that would naturally lower my estradiol and hematocrit levels.
My dosing schedule has been 16 mg on Sun, Tue, Thurs, and Sat and 12 mg on Mon, Wed, and Fri for a total of 100 mg per week.

These are my latest results.

TESTOSTERONE, TOTAL, LC/MS/MS (ng/dL) 644 (range 250-1100)

FREE TESTOSTERONE (pg/mL) 212.6 (range 35.0-155.0)

ESTRADIOL Ultrasensitive LC/MS (pg/mL) 65 (range < OR = 29)

HEMATOCRIT 48.5 (Reference Range: 38.5-50.0 %)


I'm happy with the total testosterone, but not so much with the estradiol and the hematocrit. These numbers seem to be consistent with the numbers I get from once a week and twice a week dosing.

I can't use AI's to lower estrogen because I have stage 2 kidney disease and AI's cause me to bleed and pass quarter size blood clots from my kidneys, and of course DIM doesn't do anything for me. The estradiol makes my ED much worse.

Any ideas would be greatly appreciated.

The goal was to find an injection schedule that would naturally lower my estradiol and hematocrit levels.

You should be more concerned with your FT.

High FT will drive up e2 let alone RBCs/hemoglobin/hematocrit.

Although your TT is far from too high your FT is high most likely because you have low SHBG.

Keep in mind that although some men may have high hopes that injecting lower doses of T more frequently will result in lowering of e2 and hematocrit it is not a given and in many cases regardless of the daily low dosed protocol, many make the mistake of running too high a TT/FT level let alone if one has low SHBG than even though TT may not seem that high FT will be high.


My dosing schedule has been 16 mg on Sun, Tue, Thurs, and Sat and 12 mg on Mon, Wed, and Fri for a total of 100 mg per week.

Why the alternating between 16 mg/14 mg?

Easier and more sensible to inject 14 mg daily (98 mg/week).

 

[madman]

These are my latest results.

TESTOSTERONE, TOTAL, LC/MS/MS (ng/dL) 644 (range 250-1100)

FREE TESTOSTERONE (pg/mL) 212.6 (range 35.0-155.0)

ESTRADIOL Ultrasensitive LC/MS (pg/mL) 65 (range < OR = 29)



Glad to see you did your homework.

At least you had blood work done using the most accurate assays TT/e2 (LC/MS-MS) and FT (Equilibrium Ultrafiltration).

 

[Cataceous]

In line with what @madman says, keep in mind that free testosterone is what's driving estradiol production. I would test SHBG to verify that your free testosterone is as high as the test indicates. If so I'd consider a pretty significant dose reduction, like at least 30%. One of the ways low SHBG causes problems is by driving up free estradiol relative to free testosterone. The problem has got to be worse with total estradiol so high relative to total testosterone, around 1% when 0.5% is more typical. If the ratio doesn't improve with a lower dose then an alternative to an AI is to replace some of the testosterone with nandrolone.

 

[rustylwb]

I started doing daily dosing of Test Cyp at the beginning of November. About 4 1/2 months from my most recent blood test. The goal was to find an injection schedule that would naturally lower my estradiol and hematocrit levels.
My dosing schedule has been 16 mg on Sun, Tue, Thurs, and Sat and 12 mg on Mon, Wed, and Fri for a total of 100 mg per week.

These are my latest results.

TESTOSTERONE, TOTAL, LC/MS/MS (ng/dL) 644 (range 250-1100)

FREE TESTOSTERONE (pg/mL) 212.6 (range 35.0-155.0)

ESTRADIOL Ultrasensitive LC/MS (pg/mL) 65 (range < OR = 29)

HEMATOCRIT 48.5 (Reference Range: 38.5-50.0 %)


I'm happy with the total testosterone, but not so much with the estradiol and the hematocrit. These numbers seem to be consistent with the numbers I get from once a week and twice a week dosing.

I can't use AI's to lower estrogen because I have stage 2 kidney disease and AI's cause me to bleed and pass quarter size blood clots from my kidneys, and of course DIM doesn't do anything for me. The estradiol makes my ED much worse.

Any ideas would be greatly appreciated.

I had to drop shots because my hematocrit got up to 58. In doing my research I found an article from Bayer in Germany about their long-acting Testosterone. The article showed all of the different forms of test like liquid gel's creams etc the bottom line is that the gel only has a 7% chance of causing high hematocrit. I started gel several months ago and by number fell like a rock. I was doing as much as 180 mg at LowT clinic and 100 if I got a scrip from my Dr. Now for the results. I started by applying the gel on my shoulders then I started also putting it directly on my Dick. And I swear it has made my dick 15-20% bigger in a couple of months. And I did;t start with a little dick it's smaller than it was when I was young but still over 6+ in now it a Fat Boy. The gel workers in just a few hrs you can tell when it kicks in. FYI Gel was originally made for Micro Dick in children and it made kids dicks 60% larger. If mine gets 60% I'm going to start doing Senior Porn LOL I'm 76 years old.

 

[madman]

I had to drop shots because my hematocrit got up to 58. In doing my research I found an article from Bayer in Germany about their long-acting Testosterone. The article showed all of the different forms of test like liquid gel's creams etc the bottom line is that the gel only has a 7% chance of causing high hematocrit. I started gel several months ago and by number fell like a rock. I was doing as much as 180 mg at LowT clinic and 100 if I got a scrip from my Dr. Now for the results. I started by applying the gel on my shoulders then I started also putting it directly on my Dick. And I swear it has made my dick 15-20% bigger in a couple of months. And I did;t start with a little dick it's smaller than it was when I was young but still over 6+ in now it a Fat Boy. The gel workers in just a few hrs you can tell when it kicks in. FYI Gel was originally made for Micro Dick in children and it made kids dicks 60% larger. If mine gets 60% I'm going to start doing Senior Porn LOL I'm 76 years old.

Injectable T has been shown to have a greater impact on increasing HCT compared to transdermal T.

3–18% with transdermal administration and up to 44% with injection.

In most cases when using injectable T high supra-physiological peaks post-injection and overall T levels (running too high TT/FT level) will have a big impact on increasing HCT.

Manipulating injection frequency by injecting more frequently using lower doses of T resulting in minimizing the peak--->trough and maintaining more stable levels may lessen the impact on HCT but it is not a given.

As again running very high FT levels will have a stronger impact on driving up HCT.

T formulation, the dose of T, genetics (polymorphism of the AR), age all play a role in the impact a trt protocol will have on blood markers (RBCs/hemoglobin/hematocrit).

Other factors such as sleep apnea, smoking can have a negative impact on hematocrit.


Transdermals are applied standard body application (gels/creams) or scrotal (cream).

Not directly to the penis let alone such practice will not increase the size (length/girth) post-puberty!

If anything testosterone increases NO (nitric oxide) which is a vasodilator that can make the penis appear larger/fuller.

PDE-5 inhibitors are vasodilators and enhance the effectiveness of NO.

Daily is the way to go and you will notice stronger/firmer/longer-lasting erections when erect and the penis will be fuller/plumper when flaccid let alone sensitivity/orgasms will increase due to improved blood flow and top it off that you will notice an increase in the quality of erections achieved during sleep NPT (nocturnal penile tumescence).

When you wake up in the middle of the night during NPT you will know what I mean.

Ones underlying vascular health will play a strong role in how well you respond to a said dose.

2.5-5 mg is the dose used when taking daily.

Many are using 5 mg/day but others may experience the beneficial effects when using a dose on the lower end of 2.5 mg/day.