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Postorgasmic Illness Syndrome: An Update

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Briefing Document: Postorgasmic Illness Syndrome (POIS) Source: (Zizzo, Sávio, Ramasamy, Lima, 2022) I. Executive Summary Postorgasmic Illness Syndrome (POIS) is a rare and poorly understood condition primarily affecting men, characterized by a...
Pregnenolone in Men: Help determining proper dosage and frequency
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Wondering what pregnenolone dose and frequency works best for optimizing your hormone balance on TRT? Pregnenolone, the "mother hormone" that serves as a precursor to numerous steroid hormones, requires careful dosing consideration due to its 3-4...
The hormonal regulation of men’s sexual desire, arousal, and penile erection
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Briefing Document: Hormonal Regulation of Male Sexual Desire, Arousal, and Penile Erection Source Rastrelli, G., Antonio, L., Carrier, S., Isidori, A., & Maggi, M. (2025). The hormonal regulation of men’s sexual desire, arousal, and penile...
Erection Supplements- Do They Work to Improve ED?
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Briefing: Erection Supplements and Erectile Dysfunction (ED) This briefing reviews information from the "Erection Supplements- Do They Work to Improve ED?" discussion on the Excel Male TRT Forum, focusing on the efficacy, safety, and regulatory...
The TRT Guide from ExcelMale.com
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Understanding the Symptoms, Diagnosis, and Treatment of Hypogonadism in Men Hypogonadism, a condition characterized by low testosterone levels, can significantly impact a man's quality of life. ExcelMale.com offers a comprehensive guide to help...
GLP-1 Medications (Semaglutide, etc.) Decrease Sex Drive
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Study at a Glance Title: “Assessing the Impact of GLP-1 Receptor Agonists on Sexual Desire: A Qualitative Review” Authors: H. Quaile & R. Horwitz Journal: Journal of Sexual Medicine — published 1 April 2025 Why This Matters Glucagon-like...
Overcoming Premature Ejaculation
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In this episode, we discuss premature ejaculation, a problem faced by 30-40% of men at some point in their lives. *But what defines premature ejaculation and, for that matter, what is considered a normal time to ejaculation? *10 minutes? 5...
Sex toys, wearable devices, and appliances for sexual pleasure
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Wearable sex toys and devices are commonly used by women and men worldwide. In a 2008 representative study of more than 3,000 American women and men ages 18 to 60 found that about 53% of women and nearly half of the men reported lifetime solo or...
Uso de hCG Junto a la Terapia de Reemplazo de Testosterona (Video)
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Uso de hCG Junto a la Terapia de Reemplazo de Testosterona Hola chicos, soy Nelson Vergel de ExcelMale.com. Hoy voy a explicar cómo usar hCG junto con la terapia de reemplazo de testosterona (TRT). Algunos hombres con testosterona baja necesitan...
Eroxon Gel: FDA OKs Over-the-Counter Erection Gel
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It is hard for me to believe this. Let's see when we try it out. The FDA has given MED3000 (Eroxon), the first nonprescription topical gel for treating erectile dysfunction (ED) in men over the age of 22, permission to be sold without a...
Men's Sexual Problems Linked to Low Prolactin Levels
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This is an article from 2013 that I found very interesting regarding the impact of low prolactin on men. A study involving nearly 3,000 European men aged 40 to 79 has revealed that low levels of the hormone prolactin are linked to sexual and...
Controversies with Testosterone Replacement Therapy: Lecture by Dr Khera
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As usual Nelson's Excel is where it's at! Mohit Khera, MD, MBA, MPH, Professor of Urology, F Brantley Scott Chair in Urology, Medical Director of the Laboratory for Andrology Research, Medical Director for the Scott Department of Urology...

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