Nelson Vergel
Founder, ExcelMale.com
The synthetic compound zeranol is a potent nonsteroidal growth promoter that mimics many of the effects of estradiol. Zeranol is used extensively in the United States and Canada to promote rapid and more efficient growth rates in animals used as sources of meat
A series of studies examined estrogenic activity in normal breast epithelial cells and breast cancer cells treated with zeranol. Abnormal cell growth was significant even at zeranol levels almost 30 times lower than the FDA-established limit in beef (Liu, 2002). Follow-up work demonstrated that zeranol is comparable to natural estrogen (estradiol) and the synthetic estrogen diethylstilbestrol (DES) in its ability to transform MCF-10A human breast epithelial cells to a pre-cancerous profile in vitro (Liu, 2004). Preliminary data indicate that serum from zeranol-treated beef cattle can stimulate the proliferation of normal breast epithelial cells and the transformation of breast tumor cells in vitro (Xu, 2009; Ye, 2009b).
A series of studies examined estrogenic activity in normal breast epithelial cells and breast cancer cells treated with zeranol. Abnormal cell growth was significant even at zeranol levels almost 30 times lower than the FDA-established limit in beef (Liu, 2002). Follow-up work demonstrated that zeranol is comparable to natural estrogen (estradiol) and the synthetic estrogen diethylstilbestrol (DES) in its ability to transform MCF-10A human breast epithelial cells to a pre-cancerous profile in vitro (Liu, 2004). Preliminary data indicate that serum from zeranol-treated beef cattle can stimulate the proliferation of normal breast epithelial cells and the transformation of breast tumor cells in vitro (Xu, 2009; Ye, 2009b).
