The more you research LDN, the greater it sounds. I still take it, but I am taking it at the same time as I take a Immune Suppresant, my Rheumatologist suggested I continue. She believes although the LDN is pro immune system, and the drugs are immune suppressants, it still has the potential to help. The bottom line, other than a start up period of "interesting" dreams, (not nightmares) it has no side effects. I believe it is worth trialing for everyone, it can't hurt, and just could help.