Understanding Androgens and Acne

[madman]

Androgens are a key factor in acne pathogenesis. Lawrence Green, MD, FAAD discusses how hormones help drive the skin disease.

 

[madman]

The primary role of sebum in the pathophysiology of acne vulgaris

ABSTRACT Background Sebum physiology and its contributions to acne vulgaris (AV) pathophysiology have been long debated. Within the pilosebaceous unit, androgens drive sebocyte production of sebum, comprising mono-, di-, and triglycerides (the latter converted to fatty acids); squalene...

www.excelmale.com

 

[madman]

Guidelines of care for the management of acne vulgaris

Background Acne vulgaris commonly affects adults, adolescents, and preadolescents aged 9 years or older. Objective The objective of this study was to provide evidence-based recommendations for themanagement of acne. Methods A working group conducted a systematic review and applied the...

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[samueldaisi]

Hey everyone! Androgens and acne, what a combo, right? Dr. Green really hit the nail on the head discussing how hormones play a role in this skin struggle. It's something many of us can relate to. Speaking of skin issues, I've had my fair share of battles, especially with melasma. It's been quite the journey finding effective treatments. Recently, I stumbled upon a melasma treatment that showed promising results. Pico laser worked wonders for me, offering a ray of hope in this ongoing battle.

 

[Seagal]

Why do most men only have acne during puberty?

 

[FunkOdyssey]

Why do most men only have acne during puberty?

While the explanation given in the video seems like accurate information, it only represents a small piece of the puzzle. For example, the acne that men on TRT experience often responds to E2 management, and in these cases, has apparently nothing to do with DHT.

 

[Fernando Almaguer]

While the explanation given in the video seems like accurate information, it only represents a small piece of the puzzle. For example, the acne that men on TRT experience often responds to E2 management, and in these cases, has apparently nothing to do with DHT.

Yes how do we control e2 and acne, I guess lower dose or take an ai. Although daily of eod cialas controls estrogen aswell. I find all of this helps when acne flares up.. mostly after taking hcg after a couple of weeks

 

[Seagal]

While the explanation given in the video seems like accurate information, it only represents a small piece of the puzzle. For example, the acne that men on TRT experience often responds to E2 management, and in these cases, has apparently nothing to do with DHT.

Is that your experience? I guess it's the fluctuation of hormones or the adjustment to a new normal. And as always genetics.
I had mild acne during puberty that subsided and vanished.
On TRT with androgel and now TU I haven't had acne. Maybe a bit more oily forehead now, however I had also a oily forehead while T deficient.

 

[FunkOdyssey]

Is that your experience? I guess it's the fluctuation of hormones or the adjustment to a new normal. And as always genetics.
I had mild acne during puberty that subsided and vanished.
On TRT with androgel and now TU I haven't had acne. Maybe a bit more oily forehead now, however I had also a oily forehead while T deficient.

Yes - chest and back acne eliminated with anastrazole.

Another big component with acne is insulin and IGF-1: The Relationship Between Acne Vulgaris and Insulin Resistance

SAD diet is devastating for acne while keto/carnivore is very helpful.

 

[Belekas]

No acne during puberty. No acne during many years of drinking or doing drugs, partying, not sleeping for days and destroying my body. Also no acne while low T with crashed e2. No acne while hardcore bodybuilding for 15 years and running up to 500mg ( i know pussy #s given todays brainless kids) of androgens ( test + deca + some oldschool Russian methandrestenolone) and no acne on TRT. Basically never. But I never eaten SAD diet because I'm Eastern European and been eating pretty good since I've rolled out. So my take its genetics, plus food and maybe being athletic as been involved in various forms of sport since early teens. But I had my share of other pretty harsh issues while growing up which faded with years so probably outgrew.

I'm actually eager to test my DHT as I've never tested it as its so expensive.

My 2 cents.

 

[madman]

The primary role of sebum in the pathophysiology of acne vulgaris

ABSTRACT Background Sebum physiology and its contributions to acne vulgaris (AV) pathophysiology have been long debated. Within the pilosebaceous unit, androgens drive sebocyte production of sebum, comprising mono-, di-, and triglycerides (the latter converted to fatty acids); squalene...

www.excelmale.com

*Acne vulgaris (AV) is a chronic inflammatory and immune-mediated skin condition characterized by the presence of noninflammatory (open and closed comedones) and inflammatory (papules, pustules, and nodules) lesions, primarily on the face, chest, upper back, and shoulders (1,2).

*AV is a multifactorial disease with 4 key interrelated processes driving pathophysiology: inflammation, increased sebaceous gland activity, and sebum production, follicular hyperkeratinization, and colonization of proinflammatory strains of Cutibacterium acnes (C.acnes) (1,6,7)

 

[madman]

Acne is multifactorial and not a typical symptom of high e2, yes it can play a role but DHT let alone sensitivity of the AR to DHT plays a big role.

High estradiol is not the main driver here.

Non aromatizable androgens can cause acne!

Androgenicity of the compound is key here!

 

[Nelson Vergel]

While the explanation given in the video seems like accurate information, it only represents a small piece of the puzzle. For example, the acne that men on TRT experience often responds to E2 management, and in these cases, has apparently nothing to do with DHT.

You mean anastrozole can be used as an acne treatment?

 

[FunkOdyssey]

You mean anastrozole can be used as an acne treatment?

In some men on TRT, yes.

 

[Nelson Vergel]

In some men on TRT, yes.

In 13+ years here, I have not seen anyone reporting that.