The Impact of 'Sneaky Testosterone' on Post-Prostatectomy Treatment

madman

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Nima Sharifi presents a published paper that investigates the role of testosterone in prostate cancer. Over a decade-long study, Dr. Sharifi's team discovered that a subset of men undergoing radical prostatectomy have unusually high levels of periprostatic testosterone, linked to worse clinical outcomes such as PSA recurrence or salvage radiation therapy. This surprising finding challenges conventional beliefs about androgen levels in prostate cancer risk. The research also suggests the possibility of "sneaky testosterone," facilitated by collateral blood circulation, directly contributing to prostate cancer growth. Dr. Sharifi discusses the potential of using these high dorsal testosterone levels as a biomarker for cancer recurrence risk, even mentioning non-invasive means of detection like peripheral blood draw or imaging modalities. Future research aims to explore the biological function of enriched metabolites from gonadal circulation on the prostate and the potential role of varicocelectomy.
 

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In many of the 266 men studied, testosterone concentrations in vessels around the prostate were significantly higher than in blood from their arms.
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