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Desai Sethi Urology Institute Researcher Finds “Sneaky Testosterone” Might Signal Worse Outcomes for Men with Prostate Cancer | Newswise
Findings from the newly published study in The Journal of Clinical Investigation suggest a large proportion of men have testosterone concentrations that are much higher in and around the prostate than traditional blood draws suggest. And this elevated exposure near the prostate increases the...
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The Impact of 'Sneaky Testosterone' on Post-Prostatectomy Treatment - Nima Sharifi
Nima Sharifi presents a published paper that investigates the role of testosterone in prostate cancer. Over a decade-long study, Dr. Sharifi's team discovered that a subset of men undergoing radical prostatectomy have unusually high levels of periprostatic testosterone, linked to worse clinical...
Nima Sharifi presents a published paper that investigates the role of testosterone in prostate cancer. Over a decade-long study, Dr. Sharifi's team discovered that a subset of men undergoing radical prostatectomy have unusually high levels of periprostatic testosterone, linked to worse clinical outcomes such as PSA recurrence or salvage radiation therapy. This surprising finding challenges conventional beliefs about androgen levels in prostate cancer risk. The research also suggests the possibility of "sneaky testosterone," facilitated by collateral blood circulation, directly contributing to prostate cancer growth. Dr. Sharifi discusses the potential of using these high dorsal testosterone levels as a biomarker for cancer recurrence risk, even mentioning non-invasive means of detection like peripheral blood draw or imaging modalities. Future research aims to explore the biological function of enriched metabolites from gonadal circulation on the prostate and the potential role of varicocelectomy.
