madman
Super Moderator
ABSTRACT
OBJECTIVE: Long-term results of testosterone replacement therapy (TRT) on bone mineral density (BMD) in literature are still missing. MATERIALS AND METHODS: Totally, 45 males with testosterone deficiency syndrome (TDS) underwent TRT. The mean age was 57.84 years and the follow-up period was 94.62 months. Males were treated with three-month intramuscular injections of 1000 mg testosterone undecanoate. BMD was check at beginning of treatment, after two years and after 5 years. For a statistic evaluation, nonparametric Wilcoxon test was used.
RESULTS: Mean BMD of lumbar spine was 1.067 at beginning, 1.122 after two years and 1.667 and after 5 years. The results after two and also 5 years showed a significant improvement (p < 0.001).
CONCLUSION: Authors proved a positive effect of long-term TRT on BMD of the lumbar spine. Densitometry of the whole hip showed also an improvement, but only after 5 years. Densitometry of the femoral neck was relatively stable. Important is that despite the fact that males became older, BMD values of the lumbar spine were improved (Fig. 6, Ref. 18).
Conclusion
TRT had multiple positive effects on affected males with TDS and only some suspicious side effects. Evaluation is not so simple because many signs were subjective. The authors used an objective sign densitometry in the current study. The authors proved a positive effect of the long term TRT on BMD in this long-term study in older males, not only on the lumbar spine, but also on the whole hip. Despite the fact that males became older, BMD values were improved. Long term TRT significantly improved the QoL and BMD. Examination of TST levels is an important part of follow-up also in TC survivors (with bilateral as well as unilateral disease). It is necessary to recommend TST examination and subsequent TRT (if needed) to reduce long-term complications including an impaired BMD (osteopenia/ osteoporosis).
OBJECTIVE: Long-term results of testosterone replacement therapy (TRT) on bone mineral density (BMD) in literature are still missing. MATERIALS AND METHODS: Totally, 45 males with testosterone deficiency syndrome (TDS) underwent TRT. The mean age was 57.84 years and the follow-up period was 94.62 months. Males were treated with three-month intramuscular injections of 1000 mg testosterone undecanoate. BMD was check at beginning of treatment, after two years and after 5 years. For a statistic evaluation, nonparametric Wilcoxon test was used.
RESULTS: Mean BMD of lumbar spine was 1.067 at beginning, 1.122 after two years and 1.667 and after 5 years. The results after two and also 5 years showed a significant improvement (p < 0.001).
CONCLUSION: Authors proved a positive effect of long-term TRT on BMD of the lumbar spine. Densitometry of the whole hip showed also an improvement, but only after 5 years. Densitometry of the femoral neck was relatively stable. Important is that despite the fact that males became older, BMD values of the lumbar spine were improved (Fig. 6, Ref. 18).
Conclusion
TRT had multiple positive effects on affected males with TDS and only some suspicious side effects. Evaluation is not so simple because many signs were subjective. The authors used an objective sign densitometry in the current study. The authors proved a positive effect of the long term TRT on BMD in this long-term study in older males, not only on the lumbar spine, but also on the whole hip. Despite the fact that males became older, BMD values were improved. Long term TRT significantly improved the QoL and BMD. Examination of TST levels is an important part of follow-up also in TC survivors (with bilateral as well as unilateral disease). It is necessary to recommend TST examination and subsequent TRT (if needed) to reduce long-term complications including an impaired BMD (osteopenia/ osteoporosis).
