madman
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Successful treatment of Post-orgasmic illness syndrome with human chorionic gonadotropin (2019)
Jose Bolan, Abraham Morgentaler
ABSTRACT
Post-orgasmic illness syndrome (POIS) is an uncommon condition in which men experience debilitating symptoms following orgasm, including anxiety, weakness, and lassitude. The etiology is unknown, and treatment is challenging. We present a 25y man with POIS since puberty. He dreaded ejaculation due to his subsequent symptoms. Multiple prior treatments had failed. Blood tests revealed testosterone (T) deficiency. hCG was prescribed. At 6 weeks T levels normalized with near complete resolution of symptoms. This successful result argues for hormonal investigation in men with POIS, and a trial of hCG or T therapy if total or free T is low or borderline.
Conclusions
POIS is an uncommon condition without established etiology that can be difficult to treat We here report the first successful treatment of POIS using hCG to elevate serum testosterone, resulting in prompt resolution of symptoms.
Jose Bolan, Abraham Morgentaler
ABSTRACT
Post-orgasmic illness syndrome (POIS) is an uncommon condition in which men experience debilitating symptoms following orgasm, including anxiety, weakness, and lassitude. The etiology is unknown, and treatment is challenging. We present a 25y man with POIS since puberty. He dreaded ejaculation due to his subsequent symptoms. Multiple prior treatments had failed. Blood tests revealed testosterone (T) deficiency. hCG was prescribed. At 6 weeks T levels normalized with near complete resolution of symptoms. This successful result argues for hormonal investigation in men with POIS, and a trial of hCG or T therapy if total or free T is low or borderline.
Conclusions
POIS is an uncommon condition without established etiology that can be difficult to treat We here report the first successful treatment of POIS using hCG to elevate serum testosterone, resulting in prompt resolution of symptoms.
