Skin Changes

[JWSimpkins]

Has anyone noticed that their skin has changed since starting TRT? I've found that my skin has actually become softer and smoother, which is an unexpected but welcomed side effect.

 

[GettingAnswers]

When I was on 100mg/week plus HCG I was very oily with shoulder and arm zits. That cleared up holding at 60mg plus HCG. Not sure those are good skin changes lol.

 

[JWSimpkins]

When I was on 100mg/week plus HCG I was very oily with shoulder and arm zits. That cleared up holding at 60mg plus HCG. Not sure those are good skin changes lol.

Ha! Yeah, being greasy would fall under the not good category. I too have had some issues on my chest and back with spots, but nothing unmanageable.

 

[Nelson Vergel]

I like this product for my oily face: https://www.excelmale.com/forum/thr...onal-Mattifying-Gel-for-TRT-related-oily-face

I also use Nizoral shampoo (ketoconazole, DHT blocker) as the main soap on my body when I shower.

Taking zinc (30-50 mg per day plus 3 mg copper) can also help minimize effects of DHT on the skin.

 

[JWSimpkins]

I like this product for my oily face: https://www.excelmale.com/forum/thr...onal-Mattifying-Gel-for-TRT-related-oily-face

I also use Nizoral shampoo (ketoconazole, DHT blocker) as the main soap on my body when I shower.

Taking zinc (30-50 mg per day plus 3 mg copper) can also help minimize effects of DHT on the skin.

Nelson, I've heard that Nizoral can lower testosterone levels. Is this true?

 

[Nelson Vergel]

Yes. Fluconazole (Nizoral) can lower testosterone blood levels if taken orally and you are not using testosterone replacement. It blocks DHT also.

 

[JWSimpkins]

Would it not get into your blood stream via transdermal?

 

[GettingAnswers]

For what it's worth here is some info I found

As An Antiandrogen
Although a side effect, the antiandrogen property of ketoconazole is chiefly responsible for the effectiveness of Nizoral shampoo in the treatment of hair loss.

Androgenetic alopecia is the most common form of hair loss. It involves the conversion of testosterone to DHT in hair follicles. The accumulation of DHT in the hair follicles soon leads to the rapid decline in the rate of hair growth.

There are 2 mechanisms by which ketoconazole acts as an antiandrogen.

The more important mechanism is blockage of androgen hormone syntheses at the adrenal gland and testicles. This is commonly achieved with high dose of oral ketoconazole.

Since Nizoral is a topical solution of ketoconazole and the active ingredient is poorly absorbed through the skin, this mechanism contributes very little to the effectiveness of the shampoo in hair loss treatment.

However, the oral route and androgen suppression at the testicles are responsible for the use of ketoconazole in the treatment of prostate cancer.

The second mechanism is the inhibition of androgen receptors. Ketoconazole is an antagonist at these receptors. This means that it blocks androgens such as testosterone and DHT from binding to these sites.

When these androgens are blocked from these receptors, they cannot harm hair follicles.

This is secondary mechanism for the effectiveness of oral ketoconazole pills. Even at high doses, oral ketoconazole cannot effectively block androgen receptors. However, topical ketoconazole serves as an antiandrogen chiefly by this mechanism.

The ketoconazole permeating the scalp from Nizoral shampoo can block the androgen receptors found in hair follicle cells. Therefore, Nizoral can provide a local but potent antiandrogen effect on the scalp.

By blocking DHT from binding to these receptors, Nizoral stops hair loss and allows the hair follicles to recover enough to resume the production of new hair.

Sources

http://www.drugs.com/pro/nizoral-shampoo.html

http://www.netdoctor.co.uk/skin-and-hair/medicines/nizoral-shampoo.html

http://www.hairlosstalk.com/hair-loss-treatments/nizoral/

 

[JWSimpkins]

For what it's worth here is some info I found

As An Antiandrogen
Although a side effect, the antiandrogen property of ketoconazole is chiefly responsible for the effectiveness of Nizoral shampoo in the treatment of hair loss.

Androgenetic alopecia is the most common form of hair loss. It involves the conversion of testosterone to DHT in hair follicles. The accumulation of DHT in the hair follicles soon leads to the rapid decline in the rate of hair growth.

There are 2 mechanisms by which ketoconazole acts as an antiandrogen.

The more important mechanism is blockage of androgen hormone syntheses at the adrenal gland and testicles. This is commonly achieved with high dose of oral ketoconazole.

Since Nizoral is a topical solution of ketoconazole and the active ingredient is poorly absorbed through the skin, this mechanism contributes very little to the effectiveness of the shampoo in hair loss treatment.

However, the oral route and androgen suppression at the testicles are responsible for the use of ketoconazole in the treatment of prostate cancer.

The second mechanism is the inhibition of androgen receptors. Ketoconazole is an antagonist at these receptors. This means that it blocks androgens such as testosterone and DHT from binding to these sites.

When these androgens are blocked from these receptors, they cannot harm hair follicles.

This is secondary mechanism for the effectiveness of oral ketoconazole pills. Even at high doses, oral ketoconazole cannot effectively block androgen receptors. However, topical ketoconazole serves as an antiandrogen chiefly by this mechanism.

The ketoconazole permeating the scalp from Nizoral shampoo can block the androgen receptors found in hair follicle cells. Therefore, Nizoral can provide a local but potent antiandrogen effect on the scalp.

By blocking DHT from binding to these receptors, Nizoral stops hair loss and allows the hair follicles to recover enough to resume the production of new hair.

Sources

http://www.drugs.com/pro/nizoral-shampoo.html

http://www.netdoctor.co.uk/skin-and-hair/medicines/nizoral-shampoo.html

http://www.hairlosstalk.com/hair-loss-treatments/nizoral/

Cool, thanks for the info!

 

[Michael McAlister]

Yes, my skin has changed. I am 66 and been on T Cyp for about 6 months. Most notably the crows feet around my eyes have diminished to very faint hair lines, the skin all over my body is much much smoother and very supple. My elephant hide elbows are completely smooth. I use no lotions except on my legs below my knees. People have begun challenging me when they ask and I answer my age to the point I have to show them my driver license. They argue that I am 46. I don't mind.

 

[JWSimpkins]

Yes, my skin has changed. I am 66 and been on T Cyp for about 6 months. Most notably the crows feet around my eyes have diminished to very faint hair lines, the skin all over my body is much much smoother and very supple. My elephant hide elbows are completely smooth. I use no lotions except on my legs below my knees. People have begun challenging me when they ask and I answer my age to the point I have to show them my driver license. They argue that I am 46. I don't mind.

That's excellent!