Ropinirole for antidepressant-induced sexual dysfunction.

HarryCat

Member
Found this and thought it relevant in light of the buspar thread.

Ropinirole for antidepressant-induced sexual dysfunction.


[h=3]Abstract[/b]Sexual dysfunction is a relatively common side-effect of antidepressants, occurring in approximately one-half of patients, and is associated with significant distress and treatment non-compliance. Dopaminergic agents have been reported to be helpful for the treatment of antidepressant-induced sexual dysfunction and, in this report, we examined the efficacy of the dopamine agonist ropinirole for this indication. Thirteen patients (three women, 10 men), aged 42.6 +/- 7.7 years, who reported sexual dysfunction on a stable dose of antidepressant, were treated openly with ropinirole initiated at 0.25 mg/day and titrated up to 2-4 mg/day over 4 weeks, as tolerated. Ten of the 13 took ropinirole for at least 4 weeks, one discontinued due to an adverse event and two because of lack of response. Sexual dysfunction, as assessed by the Arizona Sexual Experience Scale scores, was reduced from 18.8 +/- 3.6 to 13.8 +/- 4.3 after 4 weeks on ropinirole at a mean dose of 2.1 mg/day. Overall, seven of 13 patients (54%) were rated as responders on the Clinical Global Impression of Improvement Scale. The addition of ropinirole may represent a potentially useful treatment strategy for antidepressant-induced sexual dysfunction.
 
Umm....


[h=2]Side effects[edit][/b]Ropinirole can cause nausea, dizziness, hallucinations, orthostatic hypotension, and sudden sleep attacks during the daytime. Unusual side effects specific to D[SUB]3[/SUB] agonists such as ropinirole and pramipexolecan include hypersexuality, punding and compulsive gambling, even in patients without a history of these behaviours.[SUP][8][/SUP]
[h=2]Lawsuits[edit][/b]In November 2012, GlaxoSmithKline was ordered by a Rennes appeals court to pay Frenchman Didier Jambart 197,000 euros ($255,824); Jambart had taken ropinirole from 2003 to 2010 and exhibited risky hypersexual behavior and gambled excessively until stopping the Parkinson's treatment.[SUP][9]

https://en.wikipedia.org/wiki/Ropinirole[/SUP]
 
Umm....


Side effects[edit]

Ropinirole can cause nausea, dizziness, hallucinations, orthostatic hypotension, and sudden sleep attacks during the daytime. Unusual side effects specific to D[SUB]3[/SUB] agonists such as ropinirole and pramipexolecan include hypersexuality, punding and compulsive gambling, even in patients without a history of these behaviours.[SUP][8][/SUP]
Lawsuits[edit]

In November 2012, GlaxoSmithKline was ordered by a Rennes appeals court to pay Frenchman Didier Jambart 197,000 euros ($255,824); Jambart had taken ropinirole from 2003 to 2010 and exhibited risky hypersexual behavior and gambled excessively until stopping the Parkinson's treatment.[SUP][9]

https://en.wikipedia.org/wiki/Ropinirole[/SUP]

Yes, but that is almost all at the doses used to treat Parkinson's. The doses used in the paper I listed and the dose that I was prescribed for RLS was much lower.
I did not experience any of those sides at 4mg/day.
 
I had a sleep study done a few years ago. I was diagnosed with sleep apnea and RLS. For the sleep apnea I was prescribed an APAP machine and for the RLS I was prescribed Ropinirole. I titrated up the Ropinirole dose to about 4mg/day. I did not notice any increase in libido, most likely because I was doing 200mg shots every 2 weeks at that time. Shortly after that I left that urologist to look for someone else and I also stopped taking the Ropinorole because that is the max dose for RLS and it didn't seem to be helping that condition very much.
 

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