Resveratrol: No Impact on Metabolic Syndrome, Negatively Impacts Certain Markers

CoastWatcher · Sep 20, 2017

It's known that inflammation is associated with (among other things) metabolic syndrome and obesity. Preliminary evidence suggested that resveratrol - popular/widely used as a dietary supplement - had both anti-inflammatory and positive metabolic effects and there was hope such effects could be demonstrated in a clinical/therapeutic setting.

A randomized, placebo-controlled, double-blind study was undertaken with the enrollment of middle-aged, community-dwelling men with metabolic syndrome into one of three groups. Average age was 49.5 years, body mass index was 33.8, and waist circumference was 115 cm.
Daily oral supplementation with 1000mg of resveratrol/150mg of resveratrol/placebo for 16 weeks.
Patient blood draws measured high-sensitivity C-reactive protein (hs-CRP), circulating lipids, inflammatory markers were sought and evaluated in circulation and adipose/muscle tissue biopsy specimens, while glucose metabolism and visceral fat deposition were evaluated as well.

Results

Resveratrol did not lower circulating levels of: hs-CRP, interleukin 6, or soluble urokinase plasminogen activator receptor in plasma. Inflammatory gene expression remained unchanged in adipose and muscle tissue.
Resveratrol had no beneficial effect on blood pressure, body composition, lipid deposition in the liver or striated muscle.
Resveratrol had no beneficial effect on lipid metabolism
Resveratrol increased total cholesterol, LDL cholesterol, and fructosamine.

Journal of Clinical Endocrinology & Metabolism, 2017 May 1.

https://www.ncbi.nlm.nih.gov/m/pubmed/28182820/

Sean Mosher · Sep 20, 2017

Thank you for sharing this!
I have definitely come across a lot of info out there on Reservatrol and much hype.

CoastWatcher · Sep 20, 2017

Sean Mosher said:
Thank you for sharing this!
I have definitely come across a lot of info out there on Reservatrol and much hype.

There's no hype like the hype that can be generated by supplements.

madman · Sep 20, 2017

I personally believe there is a fine line regarding antioxidants as supplements as excess can be detrimental to ones health.
.

madhacker · Jun 9, 2020

The Effects of Resveratrol Intake on Weight Loss: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“Resveratrol supplementation significantly decreased body weight in obese patients (SMD -0.43; 95% CI, -0.60, -0.26) compared with other diseases (SMD 0.02; 95% CI, -0.29, 0.33), and type 2 diabetes mellitus (SMD -0.17; 95% CI, -0.37, 0.02). Overall, the current meta-analysis demonstrated that resveratrol intake significantly reduced weight, BMI, WC and fat mass, and significantly increased lean mass, but did not affect leptin and adiponectin levels.”

The effects of resveratrol intake on weight loss: a systematic review and meta-analysis of randomized controlled trials - PubMed

This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of resveratrol intake on weight loss. We searched the following databases until July 2018: MEDLINE, EMBASE, Web of Science and Cochrane Central Register of Controlled Trials...

pubmed.ncbi.nlm.nih.gov

Nelson Vergel · Jun 9, 2020

Resveratrol's health benefits 'overstated'

"Red wine health benefits 'overhyped'," BBC News reports. The BBC has reported on a study about a chemical called resveratrol, which is found in red wine and chocolate...

www.nhs.uk