Resveratrol: No Impact on Metabolic Syndrome, Negatively Impacts Certain Markers

CoastWatcher

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It's known that inflammation is associated with (among other things) metabolic syndrome and obesity. Preliminary evidence suggested that resveratrol - popular/widely used as a dietary supplement - had both anti-inflammatory and positive metabolic effects and there was hope such effects could be demonstrated in a clinical/therapeutic setting.

  • A randomized, placebo-controlled, double-blind study was undertaken with the enrollment of middle-aged, community-dwelling men with metabolic syndrome into one of three groups. Average age was 49.5 years, body mass index was 33.8, and waist circumference was 115 cm.
  • Daily oral supplementation with 1000mg of resveratrol/150mg of resveratrol/placebo for 16 weeks.
  • Patient blood draws measured high-sensitivity C-reactive protein (hs-CRP), circulating lipids, inflammatory markers were sought and evaluated in circulation and adipose/muscle tissue biopsy specimens, while glucose metabolism and visceral fat deposition were evaluated as well.

Results

  • Resveratrol did not lower circulating levels of: hs-CRP, interleukin 6, or soluble urokinase plasminogen activator receptor in plasma. Inflammatory gene expression remained unchanged in adipose and muscle tissue.
  • Resveratrol had no beneficial effect on blood pressure, body composition, lipid deposition in the liver or striated muscle.
  • Resveratrol had no beneficial effect on lipid metabolism
  • Resveratrol increased total cholesterol, LDL cholesterol, and fructosamine.

Journal of Clinical Endocrinology & Metabolism, 2017 May 1.

https://www.ncbi.nlm.nih.gov/m/pubmed/28182820/
 
I personally believe there is a fine line regarding antioxidants as supplements as excess can be detrimental to ones health.
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The Effects of Resveratrol Intake on Weight Loss: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“Resveratrol supplementation significantly decreased body weight in obese patients (SMD -0.43; 95% CI, -0.60, -0.26) compared with other diseases (SMD 0.02; 95% CI, -0.29, 0.33), and type 2 diabetes mellitus (SMD -0.17; 95% CI, -0.37, 0.02). Overall, the current meta-analysis demonstrated that resveratrol intake significantly reduced weight, BMI, WC and fat mass, and significantly increased lean mass, but did not affect leptin and adiponectin levels.”

 

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