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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Quest Equilibrium dialysis test - free T seems low?
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<blockquote data-quote="madman" data-source="post: 279992" data-attributes="member: 13851"><p>No way in hell your FT is lowish let alone subpar with a whopping TT 1261 ng/dL and normal SHBG.</p><p></p><p>Your FT 19.6 ng/dL based off that specific assay/reference range is high!</p><p></p><p>Even when using the cFTV your FT is well over the top-end.</p><p></p><p>Also keep in mind as of now cFTV tends to overestimate slightly when compared against a <strong><em>standardized Equilibrium Dialysis assay.</em></strong></p><p></p><p>As I have stated in previous threads Quest/Labcorp let alone any of the other labs Equilibrium Dialysis or Equilibrium Ultrafiltration assays in the US or any other country are not standardized!</p><p></p><p>Quests ED assay reference range is 35-155 pg/mL and your results are over the top-end of the reference range and well over where a healthy young male would be using the same assay.</p><p></p><p>Your FT 19.6 ng/dL is high!</p><p></p><p>Forget getting caught up in the different reference ranges for the same assays whether (ED or UF) used by different labs let alone trying to compare the results of ED vs UF, or ED/UF vs the cFT methods.</p><p></p><p>Test using the same lab/same assay (most accurate).</p><p></p><p>Compare your blood work using the same lab/same assay (most accurate).</p><p></p><p>If you choose to use/rely upon the cFT methods than stick with it.</p><p></p><p>Keep in in mind the calculated methods even have flaws.</p><p></p><p>We need accurate and standardized free testosterone assays with harmonized reference ranges!</p><p></p><p>This is key!</p><p></p><p><strong><em>* Limitations of using free testosterone by equilibrium dialysis and calculated free testosterone concentrations in practice are the <u>lack of assay standardization, an accuracy-based quality control program, and a harmonized reference range</u>. Until these <u>limitations are addressed</u>, free testosterone by equilibrium dialysis and calculated free testosterone should use <u>reference ranges established by individual laboratories or their specific assay method</u></em></strong></p><p><strong><em></em></strong></p><p><strong><em><em><strong>*The lack of <u>standardization of the equilibrium dialysis method among laboratories has been a barrier to the generation of a harmonized reference range for free testosterone levels</u>; until such <u>rigorously-derived harmonized reference ranges</u> become available, the clinicians currently must rely on <u>reference ranges provided by a laboratory or those published from the analyses of large epidemiologic studies</u></strong></em></em></strong></p><p></p><p></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/threads/age-specific-calculated-free-testosterone-ranges-in-adult-men.30243/#post-279569[/URL]</p><p></p><p></p><p>Take home points:</p><p></p><p><em><strong>*Assays that are <u>standardized are designed to provide accurate results, traceable to “true” value-assigned certified reference materials and gold-standard reference methods</u>. <u>Results obtained using standardized methods can be compared across assays, institutions, populations, and past and future test results, thereby improving diagnosis, treatment, and outcomes of patients</u></strong></em></p><p></p><p><strong><em>* Limitations of using free testosterone by equilibrium dialysis and calculated free testosterone concentrations in practice are the <u>lack of assay standardization, an accuracy-based quality control program, and a harmonized reference range</u>. Until these <u>limitations are addressed</u>, free testosterone by equilibrium dialysis and calculated free testosterone should use <u>reference ranges established by individual laboratories or their specific assay method</u></em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 279992, member: 13851"] No way in hell your FT is lowish let alone subpar with a whopping TT 1261 ng/dL and normal SHBG. Your FT 19.6 ng/dL based off that specific assay/reference range is high! Even when using the cFTV your FT is well over the top-end. Also keep in mind as of now cFTV tends to overestimate slightly when compared against a [B][I]standardized Equilibrium Dialysis assay.[/I][/B] As I have stated in previous threads Quest/Labcorp let alone any of the other labs Equilibrium Dialysis or Equilibrium Ultrafiltration assays in the US or any other country are not standardized! Quests ED assay reference range is 35-155 pg/mL and your results are over the top-end of the reference range and well over where a healthy young male would be using the same assay. Your FT 19.6 ng/dL is high! Forget getting caught up in the different reference ranges for the same assays whether (ED or UF) used by different labs let alone trying to compare the results of ED vs UF, or ED/UF vs the cFT methods. Test using the same lab/same assay (most accurate). Compare your blood work using the same lab/same assay (most accurate). If you choose to use/rely upon the cFT methods than stick with it. Keep in in mind the calculated methods even have flaws. We need accurate and standardized free testosterone assays with harmonized reference ranges! This is key! [B][I]* Limitations of using free testosterone by equilibrium dialysis and calculated free testosterone concentrations in practice are the [U]lack of assay standardization, an accuracy-based quality control program, and a harmonized reference range[/U]. Until these [U]limitations are addressed[/U], free testosterone by equilibrium dialysis and calculated free testosterone should use [U]reference ranges established by individual laboratories or their specific assay method[/U] [I][B]*The lack of [U]standardization of the equilibrium dialysis method among laboratories has been a barrier to the generation of a harmonized reference range for free testosterone levels[/U]; until such [U]rigorously-derived harmonized reference ranges[/U] become available, the clinicians currently must rely on [U]reference ranges provided by a laboratory or those published from the analyses of large epidemiologic studies[/U][/B][/I][/I][/B] [URL unfurl="true"]https://www.excelmale.com/threads/age-specific-calculated-free-testosterone-ranges-in-adult-men.30243/#post-279569[/URL] Take home points: [I][B]*Assays that are [U]standardized are designed to provide accurate results, traceable to “true” value-assigned certified reference materials and gold-standard reference methods[/U]. [U]Results obtained using standardized methods can be compared across assays, institutions, populations, and past and future test results, thereby improving diagnosis, treatment, and outcomes of patients[/U][/B][/I] [B][I]* Limitations of using free testosterone by equilibrium dialysis and calculated free testosterone concentrations in practice are the [U]lack of assay standardization, an accuracy-based quality control program, and a harmonized reference range[/U]. Until these [U]limitations are addressed[/U], free testosterone by equilibrium dialysis and calculated free testosterone should use [U]reference ranges established by individual laboratories or their specific assay method[/U][/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Quest Equilibrium dialysis test - free T seems low?
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