Nelson Vergel
Founder, ExcelMale.com
Abstract: MP48-18
Abdulmuttalip Simsek*, omer sarilar, sinan kirecci, onur kucuktopcu, faruk ozgor, fatih akbulut, erkan sonmezay, yalcýn berberoglu, gokhan gurbuz, istanbul, Turkey
American Urology Association Conf- May 2014, Orlando
Introduction and Objectives
Dapoxetine is a novel SSRI, which acts by potent inhibition of 5-HT transport. As a short acting SSRI, dapoxetine is probably better suited to use as an on-demand treatment for PE. Few studies have compared the performance of paroxetine and dapoxetine in the treatment of PE. Here we have prospectively compared safety and efficacy of daily paroxetine and dapoxetine (30 and 60 mg doses) in patients with PE.
Methods
We evaluated 150 patients (between 30 and 36 years-old) suffering from PE and referred to our outpatient clinic between May 2009 and November 2012. All patients were married potent men in stable relationship for at least 6 months and had an uncontrolled ejaculation within 1 min of vaginal intromission, with no obvious organic cause for PE Patients were divided into three equal groups of 50 patients. Group 1 patients received 30 mg dapoxetine 1-3 hours before planned intercourse. Group 2 patients received 60 mg dapoxetine 1-3 hours before planned intercourse and group 3 patients received 20 mg paroxetine once a day for a month. All patients followed up for 1 month, beginning after initiation of treatment.
Results
The average age of all the patients was 33.1 ± 3.2 yr and the mean baseline IELT was 44.9 ± 25.1 sec. There was no difference between groups in terms of age (p=0.18), body mass index (p=0.13), duration of marriage (p=0.20) or baseline IELT scores (p=0.87). The IELT increase from baseline to post-treatment was 117% in the 30 mg dapoxetine group (p<0.01), 170% in the 60 mg dapoxetine group (p<0.01), and 117% in the paroxetine group (p<0.01). The improvement of baseline IELT scores were similar for the 30 mg dapoxetine and paroxetine groups (p>0.05), whereas the improvement of IELT of 60 mg dapoxetine group was better than both the 30 mg dapoxetine (p<0.05) and paroxetine group (p<0.01) (Table 1)
Conclusions
On demand dapoxetine is a novel effective treatment modality for PE. Although a lower dose of dapoxetine (30 mg) does not outperform the currently used paroxetine treatment, 60 mg dapoxetine 1-3 hours before planned intercourse produces a greater increase in IELT for men with PE, compared to paroxetine. We propose that in cases of severe PE (e.g., IELT less than 30 sec), 60 mg dapoxetine should be given directly.
Abdulmuttalip Simsek*, omer sarilar, sinan kirecci, onur kucuktopcu, faruk ozgor, fatih akbulut, erkan sonmezay, yalcýn berberoglu, gokhan gurbuz, istanbul, Turkey
American Urology Association Conf- May 2014, Orlando
Introduction and Objectives
Dapoxetine is a novel SSRI, which acts by potent inhibition of 5-HT transport. As a short acting SSRI, dapoxetine is probably better suited to use as an on-demand treatment for PE. Few studies have compared the performance of paroxetine and dapoxetine in the treatment of PE. Here we have prospectively compared safety and efficacy of daily paroxetine and dapoxetine (30 and 60 mg doses) in patients with PE.
Methods
We evaluated 150 patients (between 30 and 36 years-old) suffering from PE and referred to our outpatient clinic between May 2009 and November 2012. All patients were married potent men in stable relationship for at least 6 months and had an uncontrolled ejaculation within 1 min of vaginal intromission, with no obvious organic cause for PE Patients were divided into three equal groups of 50 patients. Group 1 patients received 30 mg dapoxetine 1-3 hours before planned intercourse. Group 2 patients received 60 mg dapoxetine 1-3 hours before planned intercourse and group 3 patients received 20 mg paroxetine once a day for a month. All patients followed up for 1 month, beginning after initiation of treatment.
Results
The average age of all the patients was 33.1 ± 3.2 yr and the mean baseline IELT was 44.9 ± 25.1 sec. There was no difference between groups in terms of age (p=0.18), body mass index (p=0.13), duration of marriage (p=0.20) or baseline IELT scores (p=0.87). The IELT increase from baseline to post-treatment was 117% in the 30 mg dapoxetine group (p<0.01), 170% in the 60 mg dapoxetine group (p<0.01), and 117% in the paroxetine group (p<0.01). The improvement of baseline IELT scores were similar for the 30 mg dapoxetine and paroxetine groups (p>0.05), whereas the improvement of IELT of 60 mg dapoxetine group was better than both the 30 mg dapoxetine (p<0.05) and paroxetine group (p<0.01) (Table 1)
Conclusions
On demand dapoxetine is a novel effective treatment modality for PE. Although a lower dose of dapoxetine (30 mg) does not outperform the currently used paroxetine treatment, 60 mg dapoxetine 1-3 hours before planned intercourse produces a greater increase in IELT for men with PE, compared to paroxetine. We propose that in cases of severe PE (e.g., IELT less than 30 sec), 60 mg dapoxetine should be given directly.
