"We show that low total [testosterone] and [bioavailable testosterone], but not low [estradiol] or SHBG, are associated with increased falls in older men," the researchers wrote. "These data, using state-of-the-art [mass spectrometry] for assessment of serum sex steroids, confirm and extend previous findings in the U.S. MrOS cohort. Also, the effect of [testosterone] on the likelihood of falling is mediated, at least partly, by muscle mass and physical performance. Both falls and bone-strength parameters are independent predictors of fracture risk in older men. With the present data, we propose that low serum [testosterone] influences fracture risk via an increased risk of falls whereas low [estradiol] might increase fracture risk mainly through reduced bone strength."
The original article.
The original article.
