Letrozole

[danielvicente]

Double-blind, Randomized Trial of Alternative Letrozole Dosing Regimens in Postmenopausal Women with Increased Breast Cancer Risk

Aromatase inhibitors (AIs) profoundly suppress estrogen levels in postmenopausal women and are effective in breast cancer prevention among high-risk postmenopausal women. Unfortunately, AI treatment is associated with undesirable side effects that limit ...

www.ncbi.nlm.nih.gov

In vivo measurement of aromatase inhibition by letrozole (CGS 20267) in postmenopausal patients with breast cancer - PubMed

Thirteen postmenopausal women with advanced breast cancer were enrolled in an open randomized Phase I trial of a new p.o. active aromatase inhibitor, CGS 20267 (letrozole). The primary aim of the trial was to assess the impact of two doses of letrozole (0.5 and 2. 5 mg/day) on the peripheral...

pubmed.ncbi.nlm.nih.gov

What do you think?
Does letrozole 0.5mg have the same potency lower e2 as 2.5mg?

 

[Vince]

Anastrozole vs letrozole ?

"Direct comparisons of reanalyzed samples also found superior suppression of plasma estrogen levels with letrozole compared with anastrozole (Geisler et al, 2008), E2 (average suppression by 95.2 vs 92.8%), E1 (98.8% suppression vs 96.3%) E1S (98.9% suppression vs 95.3%)" I'm right? I'm my...

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