Laboratory Testing for Patients Taking Isotretinoin for Acne

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With a recent publication assessing the frequency of lab monitoring for patients with acne being treated with isotretinoin, AARS President Elect Jonathan Weiss, MD, FAAD, weighs in on the latest expert thinking. He also compares the current publication to the Guidelines of Care for Acne from the American Academy of Dermatology.

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Isotretinoin: Regulator adds prescribing safeguards after review of side effects

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Oral isotretinoin for acne

Oral isotretinoin for acne: a complete overview (2022) Alessia Villani, Francesca Nastro, Francesca Di Vico, Gabriella Fabbrocini, Maria Carmela Annunziata & Lucia Genco ABSTRACT Introduction: Acne is one of the most common and widespread skin conditions, affecting the health as much as...

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* Isotretinoin has both serotonin reuptake inhibiting and 5 alpha-reductase inhibiting properties

 

An update on the pharmacological management of acne vulgaris

* Four main interrelated pathogenic factors, that act synergistically in a complex manner are involved in the development of acne lesions: 1. Increased sebum production due to androgen-driven sebaceous gland hyperplasia; 2. Hyperkeratinization of the follicular epithelium due to abnormal...

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Guidelines of care for the management of acne vulgaris

Background Acne vulgaris commonly affects adults, adolescents, and preadolescents aged 9 years or older. Objective The objective of this study was to provide evidence-based recommendations for themanagement of acne. Methods A working group conducted a systematic review and applied the...

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The primary role of sebum in the pathophysiology of acne vulgaris

ABSTRACT Background Sebum physiology and its contributions to acne vulgaris (AV) pathophysiology have been long debated. Within the pilosebaceous unit, androgens drive sebocyte production of sebum, comprising mono-, di-, and triglycerides (the latter converted to fatty acids); squalene...

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